小剂量环孢素联合达那唑治疗慢性再生障碍性贫血效果评价.docVIP

小剂量环孢素联合达那唑治疗慢性再生障碍性贫血效果评价 　　[摘要]目的 评价小剂量环孢素联合达那唑治疗慢性再生障碍性贫血的临床效果。方法 选取2005年7月～2015年1月在我院接受诊治的46例慢性再生障碍性贫血患者作为研究对象，按随机数表法将其分为对照组和观察组（n=23）。对照组进行标量的环孢素和达那唑口服用药，观察组则进行小量的环孢素和达那唑口服用药。比较两组患者治疗前后的血象情况，起效时间，治疗的有效率及治疗后的不良反应发生率。结果 治疗后，两组患者的白细胞计数（WBC）、血红蛋白（Hb）及血小板计数（PLT）指标与治疗前比较，明显改善；观察组患者治疗的总有效率与对照组比较，差异无统计学意义（P0.05）；两组患者的起效时间比较，差异无统计学意义（P0.05）；观察组患者的不良反应发生率（21.74%）明显低于对照组（56.52%），差异有统计学意义（P0.05）。结论 小剂量环孢素联合达那唑治疗慢性再生障碍性贫血能明显降低不良反应的发生率，效果显著，适合临床推广。 　　[关键词]环孢素；慢性再生障碍性贫血；达那唑；小剂量 　　[中图分类号] R556.5 [文献标识码] A [文章编号] 1674-4721（2016）07（a）-0156-03 　　[Abstract]Objective To evaluate the clinical effects of low dose cyclosporine and danazol combination in treatment chronic aplastic anemia.Methods 46 accepted treatment chronic aplastic anemia patients from July 2005 to January 2015 of our hospital were selected as study object.Patients were divided into control group and observation group（n=23） according to random number table.Patients in control group were given oral administration standard dose cyclosporine and danazol，patients in observation group were given oral administration low dose cyclosporine and danazol.The blood situation before and after treatment，onset time，treatment effective rate and the incidence rate of adverse effects after treatment in two groups were compared.Results After treatment，the index of PLT，Hb and WBC in two groups obvious improved compared with before treatment；The effective rate between observation group and control group had no obvious difference（P0.05）；The onset time between two groups had no obvious difference（P0.05）；The incidence rate of adverse effects in observation group was 21.74%，obvious lower than that was 56.52% in control group，and the difference was statistical dignificance（P0.05）.Conclusion Using low dose cyclosporine and danazol combination in treatment chronic aplastic anemia can obvious decrease the treatment adverse effects，decrease the incidence rate of adverse effects and with obvious effects.It is suitable to popularize in clinic.