小剂量甲基强松龙治疗重症手足口病疗效分析.docVIP

小剂量甲基强松龙治疗重症手足口病疗效分析 　　[摘要]目的 探讨小剂量甲基强的松龙治疗重症手足口病的疗效。方法 选取2014年4月～2015年8月我院住院接受治疗的83例重症手足口病患儿作为研究对象，采用掷硬币法将其分为常规对照组（41例）和小剂量甲基强的松龙组（42例），常规对照组以甘露醇、利巴韦林和IVIG等进行常规治疗，小剂量甲基强的松龙组在常规对照组基础上加用1～2 mg/（kg?d）甲基强的松龙治疗，对比分析两组患儿的手足口病缓解率、脑脊液复常率、副作用发生情况以及患儿退热时间、神经系统和肺部症状消退时间、心肌酶谱恢复正常时间。结果 常规对照组手足口病缓解率为75.61%、脑脊液复常率为75.61%、退热时间为（3.39±0.77）h、神经系统消退时间为（2.79±0.575）h、肺部症状消退时间为（5.61±1.59）h，心肌酶谱恢复正常时间为（4.39±1.57）h，小剂量甲基强的松龙组手足口病缓解率为95.24%、脑脊液复常率为95.24%、退热时间为（2.51±0.41）h、神经系统消退时间为（1.51±0.21）h、肺部症状消退时间为（3.62±1.21）h、心肌酶谱恢复正常时间为（3.51±1.61）h均优于常规对照组，差异有统计学意义（P0.05）。结论 小剂量甲基强的松龙治疗重症手足口病的疗效确切，可有效改善患儿临床症状，且用药安全性高，未增加副作用，患儿可耐受，值得推广。 　　[关键词]小剂量甲基强的松龙；重症手足口病；疗效 　　[中图分类号] R174+.1 [文献标识码] A [文章编号] 1674-4721（2016）07（b）-0096-03 　　[Abstract]Objective To explore the effects of low dosage methylprednisolone in treating severe hand，foot and mouth disease.Methods 83 children patients with severe hand，foot and mouth disease from April 2014 to August 2015 of our hospital were selected as study objects and were divided into routine control group （41 cases） and low dosage methylprednisolone group （42 cases） by using coin toss method.Patients in routine control group were given mannitol，ribavirin and IVIG，while patients in low dosage methylprednisolone group were used 1～2 mg/（kg?d） methylprednisolone on the basis of routine control group.The difference of remission rate of hand，foot and mouth disease，cerebrospinal fluid recovery rate，incidence of adverse effects and children with antifebrile time，nervous system and pulmonary symptom resolution time，myocardial enzyme recovery to normal between two groups were compared.Results The remission rate of hand，foot and mouth disease，cerebrospinal fluid recovery rate，children with antifebrile time，nervous system resolution time，pulmonary symptom resolution time and myocardial enzyme recovery to normal in routine control group were respectively 75.61%，95.24%，（3.39±0.77） h，（2.79±0.575） h，（5.61±1.59） h and （4.39±1.57） h.The remission rate of hand，foot and mouth disease