布地奈德联合乙酰半胱氨酸泡腾片对支气管哮喘疗效及对NONOSROS水平影响.docVIP

布地奈德联合乙酰半胱氨酸泡腾片对支气管哮喘疗效及对NONOSROS水平影响 　　【摘要】 目的：探?布地奈德联合乙酰半胱氨酸泡腾片对支气管哮喘的疗效及对NO/NOS、ROS水平的影响。方法：选取2014年10月-2017年9月在本院治疗的支气管哮喘患者120例，根据治疗方案分为：A组（n=61）和B组（n=59），其中A组给予布地奈德治疗，B组给予布地奈德和乙酰半胱氨酸泡腾片治疗，观察各组治疗前后肺功能、NO、NOS、ROS及炎症因子水平。结果：B组治疗后FVC、FEV1%和PEF分别为（2.78±0.39）L、（73.10±10.21）%和（2.52±0.30）L/s，均明显高于A组（P0.05）；B组治疗后NO、NOS和ROS分别为（60.10±7.84）μmol/L、（30.02±5.20）U/mL和（9.84±2.33）ng/mL， 　　均明显低于A组（P0.05）；B组治疗后IL-4、IL-13和CRP分别为（4.23±0.95）pg/mL、（29.38±7.06）pg/mL 　　和（9.10±2.01）mg/L，均明显低于A组（P0.05）；NO与FVC、FEV1%和PEF呈负相关（r=-0.492、 　　-0.503和-0.477，P0.05）。结论：布地奈德联合乙酰半胱氨酸泡腾片治疗支气管哮喘患者有较好的效果，能明显改善患者肺功能，降低患者NO、NOS、ROS及炎症因水平。 　　【关键词】 支气管哮喘； 一氧化氮； 一氧化氮合酶； 活性氧； 肺功能 　　Detection and Clinical Significance of Nitric Oxide/Nitric Oxide Synthase and Reactive Oxygen Species in Peripheral Blood of Patients with Bronchial Asthma/WEI Jianping，XU Shuo，XU Yuhui.//Medical Innovation of China，2017，14（32）：029-032 　　【Abstract】 Objective：To investigate the levels of nitric oxide/nitric oxide synthase（NO/NOS） and reactive oxygen species（ROS） in peripheral blood of patients with bronchial asthma before and after treatment.Method：120 patients with bronchial asthma treated in our hospital from October 2014 to September 2017 were divided into two groups according to the treatment plan：group A（n=61） and group B（n=59），group A was treated with Budesonide，group B was received Budesonide and Acetylcysteine Effervescent Tablets treatment，the lung function，NO，NOS，ROS and inflammatory factors of two group were observed before and after treatment.Result：FVC，FEV1% and PEF in group B after treatment were （2.78±0.39）L，（73.10±10.21）%和（2.52±0.30）L/s，significantly higher than those in group A（P0.05）.NO，NOS and ROS in group B after treatment were （60.10±7.84）μmol/L，（30.02±5.20）U/mL and （9.84±2.33）ng/mL，were significantly lower than those of group A（P0.05）.IL-4，IL-13 and CRP of group B after treatment were （4.23±0.95）pg/mL， 　　（29.38±7.06）pg/mL and （9.10±2.01）mg/L，significantly lower than those of group A（P0.05）.Conclusion：Bud