己烯雌酚联合米索前列醇用于绝经后取环临床观察.docVIP

己烯雌酚联合米索前列醇用于绝经后取环临床观察 　　[摘要] 目的 探讨己烯雌酚联合米索前列醇用于绝经后取环的临床效果。 方法 选取本院2010年10月～2012年10月绝经后取环患者134例，随机分为两组，67例患者单用米索前列醇为对照组，67例患者联用己烯雌酚与米索前列醇为观察组，比较两组患者的临床指征、疼痛情况、宫颈软化程度、取环效果。 结果 观察组手术时间短于对照组，术中出血量少于对照组，疼痛情况、宫颈软化程度、取环效果明显好于对照组，差异有统计学意义（P0.05）。 结论 己烯雌酚联合米索前列醇用于绝经后取环的临床效果显著，可明显减轻患者的疼痛，提高取环成功率。 　　[关键词] 己烯雌酚；米索前列醇；绝经后取环 　　[中图分类号] R713 [文献标识码] A [文章编号] 1674-4721（2013）11（c）-0075-02 　　Clinical observation of diethylstilbestrol combined with misoprostol in IUD removal after menopause 　　REN Jie 　　Nangang Branch of Heilongjiang Hospital，Harbin 150000，China 　　[Abstract] Objective To investigate the clinical effect of diethylstilbestrol combined with misoprostol in IUD removal after menopause.Methods 134 postmenopausal women who removed IUD were selected in hospital from October 2010 to October 2012.Patients were randomly divided into two groups，67 patients treated misoprostol were as control group，67 patients treated diethylstilbestrol and misoprostol were as observation group.Clinical indications，pain，cervical soft degree，ring effect were compared.Results Operation time，intraoperative bleeding in observation group was significantly less than that of control group.Pain，cervical soft degree，ring effect in observation group was significantly better than that of control group.The difference was significant （P0.05）.Conclusion Clinical effect of diethylstilbestrol and misoprostol in IUD removal after menopause is remarkable，which can significantly reduce pain of patients and improve success rate. 　　[Key words] Diethylstilbestrol；Misoprostol；IUD removal after menopause 　　随着年龄的增加，绝经后女性会发生一系列的生理变化，体内雌激素和孕激素会大幅减少，减弱卵巢功能，其生殖器也会出现不同程度的老化，而以前置入的节育器长时间留置会嵌入到子宫内，造成后期取环非常困难，给患者带来疼痛[1-3]。术前常给予患者宫颈软化，以利于开展手术，常用药物为己烯雌酚、米索前列醇等[4-6]。本文探讨己烯雌酚与米索前列醇用于绝经后取环的临床效果，现报道如下。 　　1 资料与方法 　　1.1 一般资料 　　选取本院2010年10月～2012年10月绝经后取环患者134例，年龄48～71岁，平均（56.2±10.3）岁，孕次为1～6次，平均（2.8±1.3）次，产次为1～5次，平均（2.4±1.0）次，置环时间为2～37年，平均（19.6±7.2）年，绝经时间为1～14年，平均（4.8±1.4）年。排除患有心肺疾病、肝肾疾病、血液病的患者。将入选患者随机分为两组，67例患者单用米索前列醇为对照组，67例患