康艾注射液联合FOLFIRI方案治疗结直肠癌Meta分析.docVIP

康艾注射液联合FOLFIRI方案治疗结直肠癌Meta分析 　　[摘要]目的 探?及系统性评价康艾注射联合FOLFIRI化疗方案治疗结直肠癌的临床效果及安全性。方法 计算机检索Pubmed，the Cochrane Library，SCI，CNKI，VIP，CBM，Wan Fang Database，检索时间截至2016年8月10日。收集康艾注射液联合FOLFIRI化疗方案应用于结直肠癌的临床随机对照研究，各研究间有效率、生存质量改善率、不良反应相关数据相加组合，对比、分析两药联合组与单用FOLFIRI方案组的疗效差异。由两名研究者分别按照纳入和排除标准独立搜索选择文献、提取资料，采用Revman 5.0软件进行Meta分析。结果 共纳入4项研究，涉及患者299名。Meta分析结果显示，康艾注射液联合FOLFIRI化疗方案（联合组）与单纯FOLFIRI化疗方案组治疗后的有效率差异有统计学意义（P0.05）。结论 在治疗中晚期结直肠癌效果及减少不良反应方面，康艾注射液联合FOLFIRI化疗方案优于单纯FOLFIRI化疗方案。 　　[关键词]康艾注射液；FOLFIRI；结直肠癌；Meta分析 　　[中图分类号] R735.3+4 [文献标识码] A [文章编号] 1674-4721（2017）05（a）-0004-06 　　[Abstract]Objective To discuss and systematically evaluate the clinical effect and safety of Kangai Injection combined with FOLFIRI for the treatment of colorectal cancer.Methods Pubmed，the Cochrane Library，SCI，CNKI，VIP，CBM，Wan Fang Database were searched using computer.August 10，2016 was search deadline. Clinical randomized controlled study of Kangai Injection combined with FOLFIRI chemotherapy plan applied in colorectal cancer was collected，and the effective rate，the improvement rate of quality of life and adverse reaction related data among the studies were added and combined.Differences of curative effect of two drug combination group and single FOLFIRI group were compared and analyzed.According to the inclusion and exclusion criteria，two researchers independently selected and searched the literature，extracted the data and Meta analysis was conducted using Revman 5.0 software.Results A total of 4 studies were included involving 299 patients.Meta analysis results showed that there was a statistical difference of the effective rate between the Kangai Injection combined with FOLFIRI chemotherapy plan （the combined group） and single FOLFIRI chemotherapy plan group after treatment （P0.05）.Conclusion Kangai Injection combined with FOLFIRI chemotherapy plan is better than single FOLFIRI chemotherapy plan in the aspects of effect for treating advanced colorectal cancer and reducing the adverse reaction.