山莨菪碱对社区2型糖尿病并发肺内感染早期治疗作用研究.docVIP

山莨菪碱对社区2型糖尿病并发肺内感染早期治疗作用研究 　　[摘要] 目的 探讨山莨菪碱对社区2型糖尿病并发肺内感染早期治疗作用。 方法 将96例社区糖尿病并发肺内感染患者随机分为T组和F组，每组48例，T组为抗生素联合山莨菪碱治疗，F组分为抗生素头孢呋辛治疗。结果 T组治疗有效率为97.92%，优于F组治疗有效率（72.92%），差异有统计学意义（P0.05），两组在治疗及随访期间未见不良反应。 结论 2型糖尿病并发肺内感染患者加入山莨菪碱治疗，其效果明显优于单纯抗生素治疗效果。 　　[关键词] 山莨菪碱；2型糖尿病；肺内感染；早期治疗 　　[中图分类号] R587.1 [文献标识码] B [文章编号] 1673-9701（2018）09-0094-03 　　Study on early treatment effect of anisodamine on type 2 diabetes complicated with pulmonary infection in community 　　TAO Zhenghua1 BAI Jingli1 JIN Yanghe2 　　1.Huinan District Central Hospital of Shenyang City，Shenyang 110000，China；2.Shenyang Yingda Hospital，Shenyang 110000，China 　　[Abstract] Objective To investigate the early treatment effect of anisodamine on type 2 diabetes complicated with pulmonary infection in the community. Methods 96 patients with community-based diabetes mellitus complicated with pulmonary infection were randomly divided into T group and F group， with 48 cases in each group. T group was given antibiotics combined with anisodamine for treatment， and F group was given antibiotic of cefuroxime for treatment. Results The treatment effective rate in T group was 97.92%， which better than that in the F group（72.92%）， the difference was statistically significant（P0.05）. No adverse reactions were observed in both groups during treatment and follow-up. Conclusion Administration of anisodamine in the patients with type 2 diabetes mellitus complicated with pulmonary infection has a better curative effect than that of the antibiotic alone. 　　[Key words] Anisodamine；Type 2 diabetes；Pulmonary infection；Early treatment 　　社?^肺内感染患者每年都在增加，而近年糖尿病并发肺内感染患者的上升比例尤为明显，如何及时治疗这一并发症，成为临床工作的重要研究方向，山莨菪碱（Anisodamine，Ani）作为胆碱酯酶抑制剂，最初应用于平滑肌痉挛的治疗，以及有机磷中毒的急救[1]。后来对渗出性胸膜炎、糖尿病微循环障碍等也有很好的疗效[2]。但对其治疗糖尿病肺内感染的研究少见[3]。通过对96例肺内感染患者的观察及对其作用机制研究，证明山莨菪碱在2型糖尿病并发肺内感染治疗效果明显优于普通抗生素治疗组，为糖尿病并发肺内感染的治疗提供了临床依据，现报道如下。 　　1 资料与方法 　　1.1 一般资料 　　选择2016年9～12月社区住院治疗的2型糖尿病肺内感染患者96例为研究对象，其中应用山莨菪碱联合抗生素治疗组（T组）48例，男29例、女19例，年龄45～55岁，平均（51.00±0.54）岁，单纯抗生素治疗（F组）48例，男2