山莨菪碱非那根和双氢克尿噻联合治疗小儿秋季腹泻疗效观察.docVIP

山莨菪碱非那根和双氢克尿噻联合治疗小儿秋季腹泻疗效观察 　　[摘要] 目的:探讨山莨菪碱、非那根和双氢克尿噻联合治疗小儿秋季腹泻的疗效。方法:将193例秋季腹泻患儿随机分成对照组84例和观察组109例。对照组给予调整饮食、抗病毒、维持水电解质平衡等综合治疗;观察组加用山莨菪碱、非那根和双氢克尿噻口服治疗。结果:观察组的总有效率为97.0%,明显高于对照组的79.8%,组间差异有统计学意义(P0.01)。结论:山莨菪碱、非那根和双氢克尿噻联合治疗小儿秋季腹泻疗效确切,方便安全,值得借鉴。 　　[关键词] 山莨菪碱;非那根;双氢克尿噻;秋季腹泻 　　[中图分类号] R725.7[文献标识码]B [文章编号]1673-7210(2010)06(c)-073-02 　　 　　Efficacy of treatment of pediatric rotavirus enteritis with Anisodamine, Phenergan and Hydrochlorothiazide jointly 　　NIU Wenyuan 　　(Digestive System Department,ShanXi Children′s Hospital,Taiyuan 030001, China) 　　[Abstract] Objective: To investigate the efficacy of treatment of pediatric rotavirus enteritis with Anisodamine, Phenergan and Hydrochlorothiazide jointly. Methods: 193 cases of pediatric rotavirus enteritis were randomly divided into 84 cases of the control group and 109 cases of the observation group. The comprehensive treatment includes adjusting the diet, anti-virus, maintening the water and electrolyte balance was given to the control group; the Anisodamine, Phenergan and Hydrochlorothiazide oral-treatment was added to the observation group additionally. Results: The total effective rate of the observation group was 97.0%, it was significantly higher than 79.8% of the control group, there were significant differences between two groups (P0.01). Conclusion: The efficacy of the Anisodamine, Phenergan and Hydrochlorothiazide combination-therapy is accurate, the therapy is convenient,safe and worth learning. 　　[Key words] Anisodamine; Phenergan; Hydrochlorothiazide; Rotavirus enteritis 　　 　　秋季腹泻是婴幼儿常见的疾病,主要表现为发热、水样腹泻、 呕吐等症状,常并发脱水、电解质紊乱及酸中毒。目前临床上尚无特效治疗方法,笔者采用山莨菪碱、非那根、双氢克尿噻三种药物联合治疗,取得了良好的疗效,现报道如下; 　　1 资料与方法 　　1.1 一般资料 　　所选对象为2008年10月～2010年1月我科的住院患儿,选择193例大便轮状病毒抗原检测阳性的急性腹泻住院患儿,随机分为两组。其中,观察组109例:男58例,女51例,年龄0.05),具有可比性。 　　1.2 方法 　　两组患儿均给予调整饮食、抗病毒、维持水电解质酸碱平衡等治疗。在此基础上,观察组加用山莨菪碱0.3～0.5 mg/(kg?次)、非那根1 mg/(kg?次)、双氢克尿噻1 mg/(kg?次)口服治疗,2次/d。 　　1.3 疗效判断标准[1] 　　显效:治疗72 h内粪便性状及次数恢复正常,全身症状消失;有效:治疗72 h内粪便性状及次数明显好转,全身症状明显改善