强化他汀降脂治疗进展性脑卒中临床应用.docVIP

强化他汀降脂治疗进展性脑卒中临床应用 　　[摘要] 目的 观察强化他汀降脂方案治疗进展性脑卒中的临床效果，为进展性脑卒中的临床治疗积累更多的循证医学证据。 方法 收集汕头市潮阳区大峰医院2012年1月～2013年6月收治的进展性脑卒中患者88例，随机分为两组：对照组（n=44，常规降脂治疗）和观察组（n=44，强化他汀降脂治疗）。对比两组血脂变化、临床疗效和药物不良反应。 结果 治疗前对照组和观察组总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）的表达水平差异无统计学意义（P ＞ 0.05）。TC、LDL-C的表达水平两组治疗后均较治疗前显著减低（P ＜ 0.05或P ＜ 0.01），HDL-C的表达水平两组治疗后均较治疗前显著升高（P ＜ 0.05），而且观察组对TC、LDL-C和HDL-C表达水平的影响显著优于对照组（P ＜ 0.05）。对照组和观察组的临床治疗有效率分别为63.6%和84.1%，观察组的临床疗效显著优于对照组（P ＜ 0.05）。对照组和观察组的药物不良反应发生率分别为11.4%和13.6%，两组比较差异无统计学意义（P ＞ 0.05）。 结论 强化他汀降脂方案治疗进展性脑卒中临床效果显著，无显著药物不良反应，值得临床推广应用。 　　[关键词] 强化他汀方案；进展性脑卒中；阿托伐他汀；血脂；不良反应 　　[中图分类号] R743.3[文献标识码] A[文章编号] 1673-7210（2014）05（c）-0081-03 　　 　　Clinical application of intensive Atorvastatin treatment on blood-fat in patients with progressive ischemic stroke 　　ZHENG Bin HONG Xianglong CHEN Zexin GUO Haiqiang 　　Department of Neurology, Dafeng Hospital of Chaoyang District in Shantou City, Guangdong Province, Shantou 515154, China 　　[Abstract] Objective To observe the effects of intensive Atorvastatin treatment on blood-fat in patients with progressive ischemic stroke (PIS). Methods A total of 88 patients with PIS in the Dafeng Hospital of Chaoyang District in Shantou City from January 2012 to June 2013 were enrolled in this study. All cases were divided into two groups: control group (n=44, conventional lipid-lowering treatment) and intensive Atorvastatin treatment group (n=44, intensive Atorvastatin treatment). The changes of blood-fat, clinic effects, and adverse reactions were compared between the two groups. Results The expression of TC, LDL-C and HDL-C was not significantly different between the two groups at pretreatment (P ＞ 0.05). Compared with pretreatment, the expression of TC and LDL-C was significantly decreased at posttreatment in the two groups (P ＜ 0.05 or P ＜ 0.01). However, the expression of HDL-C was significantly increased at posttreatment in the two groups (P ＜ 0.05). The changes of TC, LDL-C and HDL-C in treatment group were significantl