急性冠脉综合征患者血巨噬细胞移动抑制因子和肿瘤坏死因子α水平改变探讨.docVIP

急性冠脉综合征患者血巨噬细胞移动抑制因子和肿瘤坏死因子α水平改变探讨 　　中图分类号:R541.4 文献标 识码:A 文章编号:1009_816X(2010)04_0265_03 　　DOI:10.3969/j.issn.1009_816X.2010.04.05 　　 　　Study on Plasma Level of Macrophage Migration Inhibitory Factor(MIF) and Tumor N ecrosis Factor_α (TNF_α)in Patients with Acute Coronary Syndrome(ACS). HUANG Yi_wei, WANG Jun, ZENG Xiang_cun, et al. Department of Cardiology, Wenzho u No.2 peoples hospital, Zhejiang 325000 China 　　[Abstract] ObjectiveTo observe plasma MIF and TNF_α levels in patients with AC S and explore their clinical significance in ACS.Methods 58 patients with ACSwere recruited, including 30 patients with acute myocardial infarction(AMI)and 2 8 patients with unstable angina(UA), 24 cases who had normal coronary angiograph y also were recruited as control group. The degree of coronary artery stenosis w as determined by Gensinis scores system. Plasma MIF level was measured by ELISAand TNF_α was measured by radioimmunoassay (RIA) method.Results The levels ofMIF and TNF_α in ACS group were significantly higher than those in control gro up(P0.01), and they were higher in AMI subgroup than in UA subgroup(P 0.01). The levels of MIF、TNF_α in ACS group were correlated with the degreeof coronary artery stenosis(P0.05).Conclusions Increased MIF and TNF_α could not o nly reflect the severity of ACS, but also predict the potential risk and the deg ree of coronary artery stenosis in the initial stage of ACS. 　　[Key words]Acute coronary syndrome; Macrophage migration inhibitory factor; Tum or necrosis factor_α; Coronary angiography 　　 　　研究表明急性冠脉综合征(ACS)斑块的不稳定性与炎症反应密切相关。巨噬细胞移动抑制 因子(MIF)和肿瘤坏死因子_α水平(TNF_α)是具有多种生物活性的重要细胞因子,参与一 系列炎症和免疫过程,在动脉粥样硬化的形成和发展过程中起到重要作用[1,2]。 本文通过对ACS患者MIF和TNF_α含量的测定,探讨其在ACS浓度的变化及临床意义。 　　 　　1 资料与方法 　　 　　1.1 一般资料:实验组均为2008年8月至2009年9月我科住院的ACS患者58例,其中男38例, 女20例,平均年龄(62.3±8.0)岁。ACS患者中急性心肌梗死(AMI)30例,不稳定型心绞痛 (UA)28例。AMI的诊断按照国内2001年的诊断标准,UA的诊断按照国内2000年“不稳定性 心绞痛诊断和治疗建议”的标准。正常对照组24例,男16例,女8例,平均年龄(59.8±8.3) 岁。58例患者均行冠状动脉造影(CAG)。排除标准包括重度炎症,或伴有主要器官功能衰竭 的病人,