恩替卡韦治疗老年失代偿期乙肝后肝硬化疗效分析及不良反应观察.docVIP

恩替卡韦治疗老年失代偿期乙肝后肝硬化疗效分析及不良反应观察 　　【摘要】 目的：观察分析恩替卡韦治疗老年失代偿期乙肝后肝硬化的效果和不良反应情况。方法：选取笔者所在医院80例老年失代偿期乙肝后肝硬化患者，采用随机数字表法分为对照组和观察组，各40例。对照组患者采用常规的护肝、保肝治疗方式进行治疗，观察组患者在此基础上使用恩替卡韦进行治疗，比较两组治疗的效果和不良反应情况。结果：经过治疗后两组患者的肝功都能得到改善，观察组的临床疗效和TBiL、ALT、AST等指标改善情况均明显优于对照组，两组比较差异均有统计学意义（P0.05）。结论：恩替卡韦治疗老年代偿期乙肝后肝硬化具有明显的效果，不良反应轻微，安全性较好，值得推广。 　　【关键词】 恩替卡韦； 老年失代偿期乙肝后肝硬化； 疗效； 不良反应 　　中图分类号 R512.6 文献标识码 A 文章编号 1674-6805（2015）33-0011-02 　　Curative Effect Observation of Entecavir in the Treatment of Senile Phase Decompensated Liver Cirrhosis after Hepatitis B and Adverse Reactions/CHEN Xiao-qin，LIN Zhi-gang.//Chinese and Foreign Medical Research，2015，13（33）：11-12 　　【Abstract】 Objective：To observe and analyse the effects of entecavir treatment in elderly patients with decompensated liver cirrhosis and the adverse reactions.Method：80 cases of elderly patients with decompensated liver cirrhosis were selected in our hospital and divided into the control group and observation group by random number table method，40 cases in each group，the control group were treated by liver protection and liver treatments on the basis of routine treatment，the observation group patients were taked entecavir treatment on the basis of the control group，compared two groups of treatment effect and adverse reactions.Result：After treatment，liver function in patients of two groups could be improved and the clinical curative effect，TBiL，ALT，AST and other indicators of observation group were significantly better than the control group，there were statistically significant（P0.05）.Conclusion：Entecavir treatment of elderly patients with compensatory phase cirrhosis after hepatitis b has obvious effect，adverse reaction is mild，security is good，and it is worth promoting. 　　【Key words】 Entecavir； Elderly decompensated liver cirrhosis after hepatitis B； Curative effect； Adverse reactions 　　First-author’s address：The Second Hospital of Sanming，Sanming 366000，China 　　doi：10.14033/j.cnki.cfmr.2015.33.005 　　失代偿期乙肝后肝硬化是由慢性乙肝逐渐发展形成的，失代偿期就