扶正抗瘤胶囊联合GP方案对晚期非小细胞肺癌血清VEGF表达和疗效影响.docVIP

扶正抗瘤胶囊联合GP方案对晚期非小细胞肺癌血清VEGF表达和疗效影响 　　【摘要】 目的：观察扶正抗瘤胶囊联合GP方案对晚期非小细胞肺癌（NSCLC）血清VEGF表达和临床疗效的影响。方法：选取2014年1月-2015年6月本院收治的晚期NSCLC患者112例作为研究对象，使用随机数字表法将其分为对照组54例和治疗组58例，对照组使用GP方案进行化疗，治疗组在对照组基础上使用扶正抗瘤胶囊6 g，3 次/d，第1～40天口服。观察两组患者治疗前后血管内皮生长因子（VEGF）水平、临床疗效、不良反应及生活质量情况。结果：两组治疗前VEGF水平比较差异无统计学意义（P0.05），治疗后均较治疗前降低，且治疗组降低更为明显，比较差异均有统计学意义（P0.05）；治疗组临床总有效率为87.93%，高于对照组的59.26%，治疗组各项不良反应发生情况均低于对照组，生活质量改善情况均优于对照组，比较差异均有统计学意义（P0.05）。结论：扶正抗瘤胶囊联合GP方案对晚期NSCLC具有良好的治疗作用，能够降低血清VEGF的表达，提高临床疗效，减轻副作用。 　　【关键词】 扶正抗瘤胶囊； GP方案； 晚期非小细胞肺癌； 血清VEGF表达 　　【Abstract】 Objective：To observe the effects of Fuzheng anti-tumor capsule combined with GP regimen for advanced non-small cell lung cancer serum VEGF expression in small cell lung cancer.Method：From January 2014 to June 2015，112 cases of advanced NSCLC in our hospital were selected as the research objects，they were divided into the 54 cases of the control group and 58 cases of the treatment group according to the random number table method.The control group was treated with GP chemotherapy，the treatment group was treated with Fuzheng anti-tumor capsule 6 g，3 times a day，1 to 40 days of oral based on the control group.The changes of vascular endothelial growth factor（VEGF），clinical efficacy，adverse reaction and quality of life of two groups were observed.Result：There was no significant difference in VEGF level of two groups before treatment（P0.05），after treatment was lower than before treatment and the treatment group decreased more significantly，the differences were statistically significant（P0.05）.The total effective rate of treatment group was 87.93%，higher than 59.26% of the control group，the incidence of adverse reactions in the treatment group were lower than that in the control group，the quality of life improvement situation was better than that of the control group，the differences were statistically significant（P0.05）.Conclusion：Fuzheng anti-tumor capsule combined with GP regimen for advanced non-small cell lung cancer has good curative effect，it