托烷司琼预防含顺铂化疗药物所致恶心呕吐临床观察.docVIP

托烷司琼预防含顺铂化疗药物所致恶心呕吐临床观察 　　[摘要]目的：观察托烷司琼预防含顺铂化疗药物所致恶心、呕吐的疗效和不良反应。方法：将入选62例接受含顺铂联合化疗的恶性肿瘤患者，随机分成两组，观察组32例病人于化疗前使用托烷司琼止吐，对照组30例病人使用昂丹司琼。观察两组病人恶心、呕吐的控制情况及不良反应。结果：托烷司琼和昂丹司琼预防化疗后恶心、呕吐的有效率无明显差异（P0.05）；但完全控制率托烷司琼优于昂丹司琼（P0.05）。两组不良反应发生率无明显差异。结论：托烷司琼能有效预防含顺铂化疗药物所致恶心、呕吐，安全性好。 　　[关键词]托烷司琼；昂丹司琼；化疗；恶心、呕吐 　　[中图分类号]R979.1 [文献标识码]A [文章编号]1673-7210（2007）03（c）-014-02 　　 　　Clinical observation of tropisetron in preventing nausea and vomiting induced by chemotherapeutic drugs including cisplain 　　WANG Jin-cai,ZHENG Ji-hai,LI Xiao-rui 　　(The First Affiliated Hospital of Xinxiang Medical College,Weihui 53100，Chian) 　　[Abstract]Objective:To observe the therapeutic effect and adverse reactions of tropisetron in preventing nausea and vomiting induced by chemotherapeutic drugs including cisplain.Methods:32 patients with cancer undergoing chemotherapy regimens including cisplain were divided randomly into 2 groups(observative group was given tropisetron before chemotherapy and control group was given ondansetron).The situation of nausea,vomiting and adverse reactions were observed and recorded.Results:There was no significant difference in the total effective rate between tropisetron and ondansetron in preventing nausea and vomiting induced by chemotherapy(P0.05).Tropisetron was superior to ondansetron in the complete control rate(P0.05).Conclusion:Tropisetron was safe and effective in preventing nausea and vomiting induced by chemotherapeutic drugs including cisplain. 　　[Key Words]Tropisetron;Ondansetron;Chemotherapy;Nausea and vomiting 　　 　　在恶性肿瘤的临床化疗中，化疗药物所致的强烈的胃肠道反应如恶心、呕吐往往成为患者能否完成治疗的一个关键因素。托烷司琼是一种中枢神经系统高效、高选择性的5-HT3受体拮抗剂，可用于预防和控制化疗药物引起的恶心、呕吐。本文观察了托烷司琼对含顺铂化疗药物治疗患者的止吐效果和不良反应，现报道如下： 　　 　　1 资料与方法 　　 　　1.1 病例选择及分组 　　入选病例62例均来自我院2005年10月～2006年9月的住院患者，经病理学或组织学证实为恶性肿瘤。其中男性36例，女性26例，年龄32～68岁，血象、肝肾功能及心电图正常，治疗前均无恶心、呕吐现象，且未应用其他止吐药。随机分为两组，其中观察组32例，接受EP方案即依托泊苷（VP-16）+顺铂（DDP）和NP方案即长春瑞滨（NVB）+顺铂（DDP）治疗各16例；对照组30例，接受EP方案和NP方案治疗各15例；两组患者在年龄、性别、病期等方面均具有可比性。 　　1.2 治疗方法 　　观察组于每日化疗前30 min静脉注入