慢性阻塞性肺疾病急性加重期患者PCT和hs―CRP水平变化及其诊断价值研究.docVIP

慢性阻塞性肺疾病急性加重期患者PCT和hs―CRP水平变化及其诊断价值研究 　　[摘要]目的 探讨慢性阻塞性肺疾病急性加重期（AECOPD）患者的血清降钙素原（PCT）和超敏C反应蛋白（hs-CRP）水平变化及其诊断价值。方法 选择2014年10月～2015年5月我院收治的60例COPD患者进行研究，按照患者病情状况分为急性加重期组和稳定期组，各30例，同时选择30例健康体检者作为对照组。分别采用发光免疫分析法定量测定PCT水平，速率散射比浊法检测hs-CRP水平。比较各组的PCT和hs-CRP水平，并观察AECOPD患者病情与以上指标的关系。结果 急性加重组的血清PCT和hs-CRP水平显著高于稳定期组和对照组，差异有统计学意义（P0.05）。稳定期组的PCT和hs-CRP水平高于对照组，差异有统计学意义（P0.05）。AECOPD感染组的PCT和hs-CRP水平显著高于未感染组，差异有统计学意义（P0.05）。结论 PCT和hs-CRP检验有利于对AECOPD患者的感染情况进行判定，诊断价值较高，值得临床推广应用。 　　[关键词]血清降钙素原；超敏C反应蛋白；慢性阻塞性肺疾病急性加重期 　　[中图分类号] R563.9 [文献标识码] A [文章编号] 1674-4721（2016）07（c）-0127-03 　　[Abstract]Objective To explore the changes of the level of PCT and hs-CRP and diagnosis value in patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD）.Methods 60 cases of COPD from October 2014 to May 2015 in our hospital were studied and divided into the acute exacerbation group and the stable group according to the patient′s condition，30 cases in each group.30 healthy people were selected as the control group.The PCT level was detected by chemiluminescence method for quantitative determination，the hs-CRP level was detected by rate than the scattering turbidity.The numerical level of CT and hs-CRP in each group was compared，and the AECOPD patients and the relationship of the above description was obversed.Results The level of PCT and hs-CRP in the acute exacerbation group was higher than that in the stable stage group and the control group，with significant difference （P0.05）.The level of PCT and hs-CRP in the stable stage group was higher than that in the control group，with significant difference （P0.05）.The level of PCT and hs-CRP in the AECOPD infection group was higher than that in the uninfected group，with significant difference （P0.05）.Conclusion PCT and hs-CRP test for diagnosis of AECOPD infection in patients has high diagnostic value，it is worthy of clinical promotion and application. 　　[Key words]Serum procalcitonin；High sensitivity C reactive protein；Acute exacerb