当归四逆汤防治放射性口腔炎咽炎临床研究.docVIP

当归四逆汤防治放射性口腔炎咽炎临床研究 　　【摘 要】 目的 观察当归四逆汤防治放射性口腔炎、咽炎的临床效果。方法 将92例欲行常规放疗的头颈部恶性肿瘤患者随机分为治疗组和对照组。治疗组以当归四逆汤为主方，对照组46例以庆大霉素＋利多卡因＋氟美松混合溶液漱口，自放疗开始至放疗结束，期间两组进行疗效对照观察。结果 治疗组放射性口腔炎、咽炎的发病率明显低于对照组（P＜0．05或P＜0．01）；治疗组有效率84．8％，对照组有效率52．2％（P＜0．05）。结论 当归四逆汤防治放射性口腔炎、咽炎效果良好，值得临床推广应用。 　　【关键词】 当归四逆汤；放射性口腔炎；放射性咽炎 　　 　　Effect of Dangguisini soup on stomatitis and pharyngitis caused by radiationLIU Qiu-lin，DING Zhao-jun，CHI Yu-hua，et al.Department of Medical Oncology,The Rizhao People′s Hospital，Rizhao China 276800 　　【Abstract】 Objective To study the clinical effect of Dangguisini soup on stomatitis and pharyngitis caused by radiation．Methods 92 cases of head-neck m alignancies who would accept conventional radiotherapy were randomly divided into treatment group and control group．Patients in the former took Dangguisini soup during radiotherapy，while those in the latter rinsed their mouths with compounds of gentamicin plus dolicaine and dexamethasone during radiotherapy．The clinical effects of the two groups were observed．Results Incidence rates of stomatitis and pharyngitis of the treatment group were less than that of control group（P＜0．05 or P＜0．01）．The effect rate of the treatment group was 84．8％,while that of the control group was 52．2％（P＜0．05）．Conclusion Dangguisi soup was effective on stomatitis and pharyngitis caused by radiation,it was worth applying more widely． 　　【Key words】 Dangguisini soup；Radioactive Stomatitis；Radioactive pharyngitis 　　当归四逆汤出自汉?张仲景之《伤寒论》厥阴篇第351条，云“手足厥寒，脉细欲绝者，当归四逆汤主之。”临床多用于血虚寒凝诸症[1]。近年来笔者用于防治头颈部癌症患者放射性口腔炎、咽炎，疗效显著，现报告如下。 　　 　　1 资料与方法 　　 　　1．1 一般资料 收集2006年1月至2007年7月在我院住院的头颈部癌症放疗患者92例，其中男51例，女41例，年龄(54±4)岁。按随机双盲法分为治疗组当归四逆汤组46例，庆大霉素＋利多卡因＋地塞米松组46例。两组在年龄、性别、分期、照射范围及剂量均衡，具有可比性(P＞0.05)。 　　1．2 方法 对头颈部癌症患者行常规放疗。治疗组30例以当归四逆汤为主方，基础剂量为：当归30 g，桂枝25 g，白芍25 g，细辛3 g，通草8 g，炙甘草12 g，大枣80 g。视患者具体病情酌情加减药量，1剂/d，水煎服。自放疗开始至放疗结束期间服用。对照组30例自放疗开始以庆大霉素＋利多卡因＋氟美松溶液漱口，具体配制方法为：0．9％生理盐水500 ml，加入庆大霉素64万U，利多卡因100 mg，地塞米松10 mg，漱口4～5次/d。疗程为自放疗开始至放疗结束。 　　1．3 疗效标准及疗效评定 　　1．3．1 疗效标准 根据RTOG急