慢性阻塞性肺疾病急性发作期合并糖尿病患者抗凝治疗及血栓前状态研究.docVIP

慢性阻塞性肺疾病急性发作期合并糖尿病患者抗凝治疗及血栓前状态研究 　　[摘要] 目的 研究慢性阻塞性肺疾病（COPD）急性发作期合并糖尿病患者的抗凝治疗及血栓前状态。 方法 选取该院于2013年12月―2017年2月收治的73例COPD急性发作期合并糖尿病患者为研究对象，随机分为两组，对照组采用常规治疗，研究组在此基础上给予抗凝治疗，比较两组患者治疗前后的血小板和血凝功能指标变化情况，以及治疗效果。 结果 两组患者采用不同方式治疗后，血小板和血凝功能指标均呈现不同程度变化，其中FIB、D-D、HB、ET、PLT指标均显著降低，研究组的降低程度均显著高于对照组（P0.05），而PT、APTT、t-PA、PAI-1指标变化差异无统计学意义，且研究组的总体有效率显著高于对照组，差异有统计学意义（P0.05）。结论 在常规药物治疗的基础上采用抗凝治疗，可有效改善慢性阻塞性肺疾病急性发作期合并糖尿病患者的血栓前状态，提高患者治疗效率和生活质量，具有良好的临床运用价值。 　　[关键词] 慢性阻塞性肺疾病；糖尿病；抗凝治疗；血栓前状态 　　[中?D分类号] R587.1 [文献标识码] A [文章编号] 1672-4062（2017）11（b）-0009-04 　　[Abstract] Objective To research the anticoagulant therapy and prethrombotic state of patients with acute exacerbation of chronic obstructive pulmonary disease combined with diabetes. Methods 73 cases of patients with COPD acute attack combined with diabetes admitted and treated in our hospital from December 2013 to February 2017 were selected as the research objects and randomly divided into two groups， the control group used the routine treatment， while the research group used the anticoagulant therapy on the basis of the control group， and the changes of platelet and hemagglutination indicators before and after treatment were compared between the two groups. Results After treatment， the FIB， D-D， HB， ET， PLT of the two groups obviously decreased， and the decrease degree in the research group was obviously higher than that in the control group（P0.05）， and there were no obvious differences in the changes of PT， APTT， t-PA， PAI-1， and the total treatment effective rate in the research group was obviously higher than that in the control group， and the differences were statistically significant（P0.05）. Conclusion The anticoagulant therapy on the basis of the routine drugs can effectively improve the prethrombotic state of patients with acute exacerbation of chronic obstructive pulmonary disease combined with diabetes and improve the treatment efficacy and quality of life， which is of good clinical application value. 　　[Key words] Chronic