拮抗剂方案与克罗米芬微刺激方案对卵巢低反应患者体外受精胚胎移植结局临床研究.docVIP

拮抗剂方案与克罗米芬微刺激方案对卵巢低反应患者体外受精胚胎移植结局临床研究 　　【摘要】 目的：探讨拮抗剂方案与克罗米芬微刺激方案在卵巢低反应（POR）患者控制性超促排卵（COH）周期中的临床效果。方法：通过对151例POR患者行体外受精-胚胎移植（IVF-ET）周期进行回顾性分析，比较拮抗剂方案102个周期（A组）和微刺激方案49个周期（B组）的临床资料和助孕结局。结果：A组促性腺激素药物（Gn）用量、Gn天数、人绒毛膜促性腺激素（hCG）注射日血清雌二醇（E2）、内膜厚度、获卵数、可利用胚胎数、优质胚胎数、均高于B组，比较差异均有统计学意义（P0.05）。结论：在POR患者促排治疗中，克罗米芬微刺激方案与拮抗剂方案相比有相近的临床结局。因此当拮抗剂方案使用受到客观限制时，克罗米芬微刺激方案可作为一种较好的替代方案。但无论哪种方案均建议取消取消新鲜周期胚胎移植， 行冻融胚胎解冻移植。 　　【关键词】 卵巢低反应； 体外受精-胚胎移植； 拮抗剂方案 　　Clinical Study on the Antagonist Regimen and Clomiphene Micro Stimulus Regimen on the Outcome of Patients with Poor Ovarian Response in Vitro Fertilization and Embryo Transplantation/LIN Xiu-feng，DU Jing，WU Chang，et al.//Medical Innovation of China，2016，13（17）：062-065 　　【Abstract】 Objective：To investigate clinical effect of antagonist regimen and Clomiphene micro stimulus regimen with poor ovarian response （POR） patients with controlled ovarian hyperstimulation ovulation （COH） cycle.Method：The 151 POR patients cycles of vitro fertilization and embryo transfer （IVF-ET） were retrospectively analyzed，the clinical data and pregnancy outcomes of antagonist regimen 102 cycles （group A）and Clomiphene micro stimulus regimen 49 cycles were compared.Result：The dosage of gonadotropin drugs （Gn），Gn days，human chorionic gonadotropin （hCG） injection day of serum estradiol （E2），endometrial thickness，number of retrieved oocytes，the number of available embryos，high quality embryo rate in group A were higher than the group B，the differences were statistically significant（P0.05）.Conclusion：In patients with POR in ovulation induction treatment，Clomiphene micro stimulus regimen compared with antagonist regimen has similar clinical outcomes.Therefore，when the use of the antagonist regimen is subject to objective constraints，Clomiphene micro stimulus regimen can be used as a good alternative.But no matter what the program is used that recommended to cancel the fresh cycle embryo transfer and use the line of frozen thawed embryo transfer. 　　【Key words】 Poor o