子痫前期患者血浆中npy nt表达水平及其临床意义的分析-expression of npy nt in plasma of preeclampsia patients and its clinical significance.docxVIP

均动脉舒张压、24 小时蛋白尿、血肌酐、ALT 均明显升高，而凝血酶原 时间较正常妊娠组低（P0.05）；轻度组平均动脉收缩压、平均动脉舒 张压、24 小时蛋白尿三个指标低于重度组（P0.05）。 3、与对照组比较而言，子痫前期轻度组和重度组血浆 NPY 和 NPY/NT 表达水平升高、NT 表达水平降低，差异有统计学意义（P0.05）； 而子痫前期两组内比较，NPY 和 NT 表达水平差异无统计学意义 （P0.05），NPY/NT 表达水平有统计学差异（P0.05）。 4、血浆 NPY、NT、NPY/NT 比值用于预测子痫前期，其 AUC 值分 别为 0.703、0.729、0.848。 结论： 1、子痫前期轻度组和重度组患者血浆中 NPY 水平显著升高， NT 水平明显降低，NPY/NT 比值明显升高。 2、血浆 NPY、NT、NPY/NT 比值均可用于预测和诊断子痫前期， 但 NPY/NT 比值的诊断价值最高。 关键词：子痫前期；神经肽 Y；神经降压素；诊断；预测； 作 者：马平红 指导老师：黄 沁 Stud Study on the expression of NPY , NT plasma level and clinical significance in Preeclampsia Abstract Study on the expression of NPY , NT plasma level and clinical significance in Preeclampsia Abstract Objective: To detect the expression of NPY and NT in preeclampsia patients in the trimester of pregnancy, and explore their relationship with preeclampsia. Investigate the predictive value of NPY and NT in preeclampsia. Methods: 73 pregnant women were chosen to for the study from January 2014 to November 2014 checked in the city of Suzhou Xiangcheng Peoples Hospital， all patients were enrolled in our clinic regular check-ups, and left early prenatal built card stored frozen plasma specimens. A total of 43 cases of preeclampsia, including 24 cases of mild patients and 19 cases of severe patients, respectively, 30 healthy pregnant women with earlier age, gestational age as as the mild and severe groups were bea control group.Collecting data of patients about pregnancy, radioimmunoassay were used to detect NT and NPY expression levels in pregnancy plasma, and correlation analysis of relevant clinical parameters. Results: The difference was not statistically significant in each group of pregnant women gestational age, gravidity, maternal ratio and body mass index(P 0.05). Compared with the control group, the average systolic blood pressure, mean arterial diastolic pressure, 24-hour proteinuria, serum creatinine, ALT were significantly increased in mild preeclampsia group and severe group, while the prothro