早期血清蛋白生化指标对不同胎龄早产儿营养评估价值.docVIP

早期血清蛋白生化指标对不同胎龄早产儿营养评估价值 　　[摘要] 目的 通过测定不同胎龄、不同相对体质量早产儿早期血清白蛋白、前白蛋白及总蛋白水平，探讨早产儿早期蛋白生化指标对评价早产儿成熟度、宫内营养状况以指导营养支持治疗的临床意义。 方法 选取2010年1月～2013年8月同期住院的新生儿189例，分为≤28周组16例、28～32周组53例、32～37周组72例、足月儿组48例。于出生后24h内采集静脉血2mL，测定白蛋白、前白蛋白、总蛋白水平。 结果 四个胎龄组间，胎龄越小，白蛋白、前白蛋白、总蛋白水平越低，差异具有统计学意义（P0.05）。各胎龄组内不同相对体质量间白蛋白、总蛋白水平差异无统计学意义（P0.05）。 结论 早产儿胎龄越小，白蛋白、前白蛋白、总蛋白水平越低，前白蛋白是目前评价早产儿成熟度及营养状况最敏感的指标。监测早产儿血清蛋白水平变化，对临床合理营养支持治疗及预防疾病具有指导意义。 　　[关键词] 早产儿；前白蛋白；白蛋白；营养评估 　　[中图分类号] R722.6 [文献标识码] A [文章编号] 2095-0616（2014）03-22-05 　　complications after birth such as feeding difficulty， which is prone to protein deficiency.The early nutrition condition is not only to decide whether the premature babies can survive but also has a lasting impact on their long-term quality of life [1].In this paper，the assessment value of early serum biochemical indexes to the maturity and intrauterine nutrition statue of the premature infant and its guiding significance for nutrition support therapy in clinical are discussed by detecting the levels of early serum albumin （ALB），prealbumin （PA） and total proteins （TP） of the premature infants at different gestational ages with different relative body weight （RBW）. 　　1 Materials and Methods 　　1.1 General Information 　　（1） Research object：189 newborns admitted in NICU of the affiliated hospital of Qingdao university between 2010-01 and 2013-08；（2） Inclusion criteria： neither infection was observed in the research objects and their pregnant mothers，nor the congenital malformations，genetic metabolic disease and severe liver and kidney dysfunction. 　　1.2 Methods 　　Collection of clinical data.Infants were divided into groups according to the gestational age：there were 16 cases in??28 weeks group，where 7 cases were male and 9 cases were female；53 cases in the 28+1-32 weeks group （namely28 weeks and ≤32 weeks），29 cases were male and 24 cases were female； 72 cases in 32+1-36+6 weeks （namely 32 weeks and 　　1.3 Statistical methods 　　Results in each group are expressed in mean±st