眼科植入材料的临床应用及生物相容性评价jlydbnpa.docVIP

眼科植入材料的临床应用及生物相容性评价 中国组织工程研究与临床康复73誊42筋2009—10—15出版 JournalofClinicalRehabilitativeTissueEngineeringResearchOctober15,2009Vo1.73No. 42.综 眼科植入材料的临床应用及生物相容性评价 张卫星,李春亮,王方 Clinicalapplicationandbiocompatibilityofophthalmicimplants ZhangWei—xing, LiChun.1ian,WangFang Abstract:AnideaIophthalmicimplantcharacterizesbystablephysicalandchemicaIpropertiesandexcellentcompatibility ArtificialIensandcorneashavebeenwidelyusedinrecent.Ipatibilitybetweenartificiallensandcorneas becomesahottopicintheresearchfieldofophthalmologyThisstudyretrievedarticlesaddressingClinicaIapplicationand hostcompatibilityofartificia¨ensandcorneas.Theanalysisreleasedthatophthalmicimplantshavebeenfrequentlyusedjn clinicaIapplication.COllagenhadpoorcompatibilitytochitosan.Additionally.theintegrationwithhostwasalsopoor. Degradationvelocitydidnotmatchtogenerationvelocityoftissues:furthermore,theydidnothaveSUdacespecificity.On lheotherhand,fibrin,amnion,polyglycoliCacid,andpolylactic—CO—glycoliCacidwhichwereconsideredasstentfortissue defectandtissueengineeringhadgreatcompatibility.Moreover,artificialsiliconegellens,artificialpolymethylmethacrylate Iens.andartificiaImemoryIensalsohadgreatcompatibilityArtificialhydrogelIenswereeasilydisplacedthUStheyeasily sufferedfrOmdelayedcalciumdepositionandhadpoorcompatibilityInfurtherstudiescompatibilitybetweenophthalmic implantsandhostneedstObeenhanced ZhangWX,LiCL,WangF.ClinicalapplicationandbiocompatibilityofophthalmicimplantsZhongguoZuzhiGongchengYanjiuyu LinchuangKangfu2009;13(42):8333—8336【】 摘要:理想的眼科材料,应具有物理化学性质稳定,生物相容性好等特点.在眼科的生物材料中,目前应用最广的就是人 工晶体材料和人工角膜材料,探讨人工晶体材料和人工角膜材料的生物相容性,成为了目前眼科领域研究的热点.文章采 用文献检索的方式,从人工晶体材料和人工角膜材料的临床应用及与宿主间的生物相容性两方面检索了相关国内外文献. 分析并总结文献内容,发现眼科植入材料的临床应用十分广泛,人工角膜的生物材料中,胶原和壳聚糖的生物相容性较 差,其材料与宿主的整合性差,降解速度与新生组织的生成速率不匹配,材料缺乏表面特异性.而纤维蛋白,羊膜,聚羟 基乙酸和聚乳酸聚羟基乙酸可作为组织缺损材料及组织工程的角膜支架材料,生物相容性较好.硅凝胶人工晶体,聚甲基 丙烯酸甲酯人工晶状体,记忆人工晶状体材料的生物相容性较好.水凝胶人工晶状体易移位,可发生迟发性钙沉积,生物 相容性较差.眼科植入材料与宿主间的生物相容性仍需提高. 关键词:人工角膜;人工晶体;眼科;生物相容性 doi:10.3969~issn.1673—8225.200942.030 张卫星,李春亮,王方眼科植入材料的