核转录因子cMYC在弥漫大B细胞淋巴瘤亚型中表达及意义.docVIP

核转录因子cMYC在弥漫大B细胞淋巴瘤亚型中表达及意义 　　[摘要] 目的 探讨不同亚型弥漫大B细胞淋巴瘤（DLBCL）组织中核转录因子κB （NF-κB）、原癌基因cMYC的表达及临床意义。 ABC-DLBCL 亚型，NF-κB、cMYC的表达与生存相关。在GCB-DLBCL亚型中，NF-κB和cMYC的阳性或阴性表达与总生存不相关。 结论 NF-κB、cMYC在ABC-DLBCL亚型表达率高于GCB-DLBCL亚型，同时可能是影响ABC-DLBCL亚型预后的不利因素。 　　[关键词] 非霍奇金淋巴瘤；弥漫大B细胞淋巴瘤；核转录因子NF-κB 　　[中图分类号] R733.1 [文献标识码] A [文章编号] 1673-7210（2014）04（b）-0010-04 　　[Abstract] Objective To investigate the clinical significance and expression of determination of nuclear transcription factor κB （NF-κB）， and cellular myelocytomatosis oncogene （cMYC）， in patients of different subtypes of diffuse large B cell lymphoma （DLBCL）. Methods The expressions of NF-κB and cMYC in diffuse large B cell lymphoma in 57 cases were detected by immunohistochemistry. And its relationship with clinical pathological characteristics was analyzed. Results The positive expression of NF-κB was related with international prognosis index （IPI） and pathological subtype， pathological subtype the positive expression of cMYC was related with pathological subtype. The expression of NF-κB in ABC-DLBCL was significantly higher than that in GCB-DLBCL， positive rate of pathological subtypepathological subtypeits expression in ABC-DLBCL， GCB-DLBCL tissues were 72.7%， 41.6% respectively， there was significant difference between two groups （P = 0.029）. The expression of cMYC in ABC-DLBCL was significantly higher than that in GCB-DLBCL， its expression in ABC-DLBCL， GCB-DLBCL tissues were 66.7%， 54.4% respectively， there was statistical difference between two groups （P = 0.035）. In ABC-DLBCL subtype， the expression of NF-κB and cMYC were related with overall survival. In GCB-DLBCL subtype， the expression of NF-κB and cMYC were not related with overall survival. Conclusion The expression of NF-κB and cMYC in ABC-DLBCL are significantly higher than those in GCB-DLBCL. In the same time， they may be adverse prognostic factors for ABC-DLBCL subtype. 　　[Key words] Non Hodgkin lymphoma； Diffuse large B cell lymphoma； NF-κB 　　弥漫大B细胞淋巴瘤（d