桃树根水煎液对大鼠实验性牙周炎治疗作用.docVIP

桃树根水煎液对大鼠实验性牙周炎治疗作用 　　【摘要】目的：观察桃树根水煎液对大鼠实验性牙周炎的治疗作用。方法：通过对大鼠第一磨牙牙颈部正畸钢丝结扎+高糖饮食+糖皮质激素注射+牙龈卟啉单胞菌感染的方法建立大鼠牙周炎模型。模型建立后分组给予布洛芬、桃树根水煎液，采取灌胃和洗漱两种不同方式进行治疗，观察实验结果。结果：大鼠实验性牙周炎模型建立成功，给予布洛芬、桃树根水煎液灌胃的方法均能使牙周炎模型大鼠食量增加，体重加重，牙周红肿出血，牙齿松动等情况改善，而布洛芬效果优于桃树根水煎液。而给予布洛芬、桃树根水煎液采用洗漱的方法治疗也能使大鼠牙周炎症状改善，但是桃树根水煎液效果却优于布洛芬灌胃和洗漱。病理检查结果显示模型组牙龈充血糜烂，炎细胞浸润，牙周软组织脓肿，牙龈沟内可见牙菌斑形成聚集。结论：桃树根水煎液洗漱法对大鼠实验性牙周炎模型有较好的治疗作用。 　　【关键词】 牙周炎；桃树根；布洛芬；治疗作用 　　【中图分类号】R285.5 【文献标志码】 A 【文章编号】1007-8517（2016）16-0020-03 　　Abstract：Objective To observe the therapeutic effect of peach root water decoction on experimental periodontitis in rat. Method Firstly， establish the rat periodontitis model by orthodontic wires ligation on the second molar tooth neck， high sugar diet， glucocorticoid injection and lindsey whew single-celled bacteria infection. Then give the rats ibuprofen and peach root water decoction by the method of gavage and gastric lavage for treatment. Observe the results. Result Experimental Periodontitis in rat successful established. Both ibuprofen and peach root water decoction given by gavage can lead to an increase in appetite and weight， periodontal reddening and swelling， and improvement in gomphiasis. The effect of ibuprofen is better than peach root water decoction. Ibuprofen and peach root water decoction given by gastric lavage can also lead to improvement in the conditions of rats with periodontitis， but peach root water decoctions effect is better than ibuprofen， gavage or gastric lavage. Pathological examination shows that the model group rats have congestive erosion in gum， inflammatory cell infiltration， abscess in periodontal tissue， and aggregation of dental plaques. Conclusion Peach root water decoction gastric lavage has a better therapeutic effect for experimental periodontitis in rat. 　　Keywords：Periodontitis；Peach Root；Ibuprofen；Therapeutic Effect 　　国内外对牙周炎的研究颇多，已经有了完整试验模型与方式。本实验旨在于研究桃树根水煎液对于实验性大鼠牙周炎的治疗作用。因多年来在溧阳有多例治愈病例，且与其同科的柳树根部明确有消炎止痛的作用，所以本实验有一定的临床与实验基础。牙周炎是日常生活中的常见疾病，因其难以治愈、疼痛感强严重影响了人们的