润燥止痒胶囊联合阿达帕林凝胶治疗寻常性痤疮临床探讨.docVIP

润燥止痒胶囊联合阿达帕林凝胶治疗寻常性痤疮临床探讨 　　[摘要] 目的 探索润燥止痒胶囊联合阿达帕林凝胶治疗寻常性痤疮的临床效果。方法 方便选取2016年6月―2017年6月期间该院收治的100例寻常性痤疮患者，将其抽签化分组，两组各有50例，对照组和观察组分别采用阿奇霉素治疗和润燥止痒胶囊联合阿达帕林凝胶治疗。 结果 观察组患者的不良事件发生率（4.00%）、总有效率（96.00%）、治疗后3 d临床症状评分（1.33±0.41）分、治疗后14 d临床症状评分（0.42±0.31）分、治疗后3 d皮损评分（1.25±0.43）分、治疗后14 d损评分（0.31±0.42）分、心理功能（96.35±2.33）分、躯体功能（98.42±0.12）分、物质生活（97.25±1.62）分、社会功能（96.12±1.76）分均优于对照组，差异有统计学意义（P0.05）。 结论 对寻常性痤疮患者实施润燥止痒胶囊联合阿达帕林凝胶治疗，安全性较高。 　　[关键词] 润燥止痒胶囊；阿达帕林；寻常性痤疮 　　[中图分类号] R758 [文献标识码] A [文章编号] 1674-0742（2017）12（a）-0113-03 　　[Abstract] Objective To explore the clinical effect of runzao zhiyang capsule and adapalene gel in treatment of acne vulgaris. Methods 100 cases of patients with acne vulgaris admitted and treated in our hospital. From June 2016 to June 2017 were convenient selected and randomly divided into two groups with 50 cases in each， the control group were treated with azithromycin， while the observation group were treated with runzao zhiyang capsule and adapalene gel. Results The incidence rate of adverse events， total effective rate， clinical symptoms scores after 3 d treatment and 14 d treatment， skin defect scores after 3 d treatment and 14 d treatment， mental function， somatic function， material life， and social function were respectively 4.00%， 96.00%，（1.33±0.41）points，（0.42±0.31）points，（1.25±0.43）points，（0.31±0.42）points，（96.35±2.33）points，（98.42±0.12）points，（97.25±1.62）points，（96.12±1.76）points， which were better than those in the control group，the difference was statistically significant（P0.05）. Conclusion The safety of runzao zhiyang capsule and adapalene gel in treatment of acne vulgaris is higher. 　　[Key words] Runzao zhiyang capsule； Adapalene； Acne vulgaris 　　近年?恚?随着时代的进步，人们生活方式节奏逐渐改变，且饮食规律也多元化，导致寻常性痤疮发生率逐渐上升，其属于皮肤科常见、好发病，具有病程长、发病急骤、预后差等特点，好发于青春期，主要临床特征为瘢痕、囊肿、结节、脓疱、丘疹、粉刺等，属于慢性炎症病变[1]。其发病因素较多，可与炎性介质、炎症、丙酸棒状杆菌增生、毛囊皮脂腺导管的过度角化、皮脂分泌增加、雄激素有关[2]。从中医角度分析，其可因阴阳失调、外感毒邪、饮食不节引起，因此治疗原则为清热除湿凉血[3]。该院在2016年6月―2017年6月23日期间收集100例寻常性痤疮患者为探索对象，且随机分组，分别实施了润燥止痒胶囊联合阿达帕林凝胶治疗