济生肾气丸加减治疗脾肾阳虚型糖尿病肾病疗效观察.docVIP

济生肾气丸加减治疗脾肾阳虚型糖尿病肾病疗效观察 　　【摘要】 目的 探讨济生肾气丸加减治疗脾肾阳虚型糖尿病肾病的疗效及对肾功能的影响。 　　方法 86例脾肾阳虚型糖尿病肾病患者， 采用随机法分为对照组和观察组， 每组43例。对照组使用常规西医治疗， 观察组在对照组基础上使用济生肾气丸加减治疗。观察比较两组患者临床疗效以及肾功能变化情况。结果 观察组总有效率为95.35% 高于对照组的76.74%， 差异有统计学意义（P0.05）；观察组空腹血糖 （FBG）为 （7.06±1.48）mmol/L、餐后2 h血糖（2 h PBG）为（8.28±1.56）mmol/L、24 h蛋白尿定量为（144.18±9.78）mg低于对照组的（8.43±1.56）mmol/L、（9.59±2.41）mmol/L、（188.46±9.52）mg， 而肌酐清除率（Ccr）为（42.01±4.36）ml/min高于对照组的（35.41±3.91）ml/min， 差异有统计学意义（P0.05）。?^察组肢体浮肿、便溏、乏力和夜尿频多等中医症状积分明显低于对照组， 差异有统计学意义（P0.05）。结论 针对脾肾阳虚型糖尿病患者， 常规西医治疗效果欠佳， 结合济生肾气丸加减治疗却可明显改善临床效果， 促进患者康复， 提升患者肾脏功能， 值得广泛推广。 　　【关键词】 糖尿病肾病；济生肾气丸加减；脾肾阳虚型；临床疗效；肾功能 　　DOI：10.14163/j.cnki.11-5547/r.2018.14.006 　　Observation on efficacy of addition and subtraction of Jisheng Shenqi pill on diabetic nephropathy of spleen-kidney and yang deficiency type LI Min-ji， ZHANG Shao-fen， PAN Zhuo-wen. Zhaoqing Gaoyao District People’s Hospital， Zhaoqing 526040， China 　　【Abstract】 Objective To discuss the effect of addition and subtraction of Jisheng Shenqi pill on diabetic nephropathy of spleen-kidney and yang deficiency type and its influence on renal function. Methods A total of 86 patients with diabetic nephropathy of spleen-kidney and yang deficiency type were divided by random method into control group and observation group， with 43 cases in each group. The control group received conventional Western medicine therapy， and the observation group received addition and subtraction of Jisheng Shenqi pill on the basis of the control group. The clinical efficacy and renal function changes between the two groups was observed and compared. Results The observation group had higher total effective rate as 95.35% than 76.74% in the control group， and the difference was statistically significant （P0.05）. The observation group had lower fasting blood glucose （FBG） as （7.06±1.48） mmol/L， postprandial 2 h blood glucose （2 h PBG） as （8.28±1.56） mmol/L 　　and 24-hour proteinuria as （144.18±9.78） mg than （8.43±1.56）mmol/L， （9.59±2.41） mmol/L and（188.4