瑞舒伐他汀强化降脂对缺血性脑卒中患者血管内皮功能影响及疗效观察.docVIP

瑞舒伐他汀强化降脂对缺血性脑卒中患者血管内皮功能影响及疗效观察 　　[摘要] 目的 探?瑞舒伐他汀强化降脂对缺血性脑卒中患者血管内皮功能的影响及疗效。方法 将90例急性脑梗死患者随机分为强化组（n=45）和普通组（n=45）。两组均予以控制颅内压、血压和血糖、抑制血小板聚集、神经保护等基础治疗。普通组在此基础上口服瑞舒伐他汀片10 mg，1次/d；强化组在此基础上口服瑞舒伐他汀片20 mg，1次/d，两组均连用8周。检测并比较两组治疗前后血清血管性假血友病因子（vWF）、血栓调节蛋白（TM）和血管内皮细胞钙黏蛋白（VE-cadherin）水平的变化，并比较其临床效果及不良反应。结果 治疗8周后，两组血清vWF、TM和VE-cadherin水平较前均不同程度下降，且强化组下降幅度比普通组更显著（P0.05）。结论 瑞舒伐他汀强化降脂治疗缺血性脑卒中的疗效显著，能明显改善其神经功能缺损程度，安全性较好，其作用机制与其能降低血清vWF、TM和VE-cadherin水平，修复受损的血管内皮，减少动脉易损斑块破裂，提高其稳定性密切相关。 　　[关键词] 缺血性脑卒中；瑞舒伐他汀；强化降脂；血管性假血友病因子；血栓调节蛋白；血管内皮细胞钙黏蛋白 　　[中图分类号] R743.3 [文献标识码] B [文章编号] 1673-9701（2018）01-0039-04 　　Influence and curative effect observation of rosuvastatin intensive lipid-lowering on vascular endothelial function of patients with ischemic stroke 　　PANG Xiu’e1 SUN Hongxia1 HONG Wenwu1 GAN Quan2 CHEN Guang2 　　1.Department of Neurology， Tiantai People’s Hospital in Zhejiang Province，Tiantai 317200；2.VIP Department， Taizhou Hospital of Taizhou Enze Medical Center （Group）， Taizhou 317000，China 　　[Abstract] Objective To discuss the influence and curative effect observation of rosuvastatin intensive lipid-lowering on vascular endothelial function of patients with ischemic stroke. Methods 90 cases of patients with ischemic stroke were divided into strengthened group （n=45） and ordinary group （n=45）. The patients in two groups were given basic medical treatment， such as reducing intracranial pressure and dehydration， control of blood pressure and blood sugar， antiplatelet aggregation， neural protection and etc. The patients in ordinary group were given oral 10mg rosuvastatin Calcium Tablets， once a day， while the patients in strengthened group were additionally given 20 mg rosuvastatin Calcium Tablets， once a day for 8 weeks. The changes of serum Von willebrand factor（vWF）， Thrombomodulin（TM）and Vascular Endothelial-Cadherin （VE-Cadherin）levels of patients in two groups before and after medical treatment were detected， and the clinical curative effect and drug adverse reaction（DAR） were