甘精胰岛素联合拜糖平对老年2型糖尿病氧自由基代谢影响.docVIP

甘精胰岛素联合拜糖平对老年2型糖尿病氧自由基代谢影响 　　[摘要] 目的 研究对比甘精胰岛素联合拜糖平及瑞格列奈联合拜糖平两种治疗方案对老年2型糖尿病患者体内氧化应激的影响。 方法 将120例老年2型糖尿病患者随机分成两组：甘精胰岛素联合拜糖平组（A组）、瑞格列奈联合拜糖平组（B组），每组60例，均接受6周的降糖治疗，选取20例体检健康者作为对照组。检测患者的一般情况以及治疗前后的血糖、一氧化氮（NO）、超氧化物歧化酶（SOD）、8-异前列腺素（8-iso-PGF2a）、丙二醛（MDA）、同型半胱氨酸（Hcy）等指标。 结果 老年糖尿病患者治疗前FPG、2 h PG、血清8-iso-PGF2a、MDA、Hcy较对照组高，NO、SOD较对照组低，差异有统计学意义（P 0.05），A组患者血清8-iso-PGF2a、MDA、Hcy较B组下降幅度大，血清NO、SOD较B组升高幅度大，差异有统计学意义（P 0.05）。 结论 甘精胰岛素联合拜糖平治疗在改善糖尿病患者体内氧化应激状态上较瑞格列奈联合拜糖平治疗更为显著。 　　[关键词] 2型糖尿病;氧自由基;甘精胰岛素;瑞格列奈;拜糖平 　　[中图分类号] R587 [文献标识码] A [文章编号] 1673-7210（2015）01（a）-0071-04 　　Effect of insulin glargine combined with acarbose for the oxygen free radical metabolism in elderly patients with type 2 diabetes 　　LIU Wenhao1 ZHANG Shufeng2 CHENG Lixia3 LU Hongwen3 CHEN Liang2 　　1.Weifang Medical University， Shandong Province， Weifang 261041， China; 2.Department of Health， Weifang Peoples Hospital， Shandong Province， Weifang 261041， China; 3.Department of Endocrinology， Weifang Peoples Hospital， Shandong Province， Weifang 261041， China 　　[Abstract] Objective To study and compare the effects of glargine combined with acarbose and Repaglinide combined with acarbose for oxidative stress in elderly patients with type 2 diabetes. Methods One hundred and twenty cases of elderly patients with type 2 diabetes were randomly divided into 2 groups： glargine combined with acarbose group （group A）， Repaglinide combined with acarbose group （group B）， each group of 60 patients， they were all treated for 6 weeks of antidiabetic therapy. 20 cases of medical healthy subjects were selected as control group. The general situation and blood glucose， nitric oxide （NO）， superoxide dismutase （SOD）， 8-isoprostane （8-iso-PGF2a）， malondialdehyde （MDA）， homocysteine （Hcy）， and so on before and after treatment were detected. Results The FPG， 2 h PG， serum MDA， 8-iso-PGF2a， Hcy of elderly patients with diabetes were increased before treatment compared with the control group， while NO， S