滑膜切除对初次全膝关节置换术治疗膝骨关节炎临床疗效Meta分析.docVIP

滑膜切除对初次全膝关节置换术治疗膝骨关节炎临床疗效Meta分析 　　【摘 要】目的：系?y评价滑膜切除对初次全膝关节置换术治疗膝骨关节炎临床疗效的影响。方法：计算机检索中国知网、万方、维普、中国生物医学文献数据库、PubMed、Embase、Cochrane Library、web of science等数据库收录的关于全膝关节置换术中是否同时行滑膜切除的临床随机对照研究，检索时间为建库至2016年12月12日。采用RevMan 5.3软件进行Meta分析。结果：共纳入6篇文献，1016例患者，518例予以滑膜切除，498例不予切除。Meta分析结果显示，与不切除组相比，滑膜切除组显著增加了手术时间（WMD = 8.40，95%CI = [0.90，15.90]，P 0.05）、隐性失血量（WMD = 0.19，95%CI = [0.11，0.28]，P 0.000 01）、引流量（WMD = 0.19，95%CI = [0.08，0.31]，P = 0.001）；2组间术后VAS评分（WMD = -1.23，95%CI = [-2.51，-0.05]，P = 0.06）、KSS评分（临床评分WMD = -0.48，95%CI = [-1.34，0.37]，P = 0.27）、功能评分（WMD = 0.14，95%CI = [-0.39，0.68]，P = 0.60）、术后关节活动度（WMD = -0.97，95%CI = [-4.92，2.97]，P = 0.63）、输血率（RR = 1.00，95%CI = [0.84，1.20]，P = 0.99）、术后浮髌试验阳性率（RR = 0.92，95%CI = [0.66，1.29]，P = 0.64），差异均无统计学意义。结论：基于有限的临床研究文献，本系统评价初步认为，全膝关节置换术中滑膜切除与不切除相比，无明显优势。 　　【关键词】 骨关节炎，膝；滑膜切除；全膝关节置换术；疗效；Meta分析 　　【ABSTRACT】Objective：To systematically evaluate the effect of synovectomy on the treatment of knee osteoarthritis with primary total knee arthroplasty.Methods：Databases such as CNKI，Wan Fang，VIP，CBMdisc，PubMed，Embase，Cochrane Library，Web of Science were retrieved for randomized control trials on whether total knee arthroplasty and synovectomy could be made at the same time（for the establishment of datebases to December 12th，2016）.Software RevMan 5.3 was used for Meta-analysis.Results：A total of 6 papers were collected，including 1016 patients，among which 518 cases had undergone synovectomy and 498 cases had not.Meta-analysis showed that synovectomy obviously increased operation time（WMD = 8.40，95%CI = [0.90，15.90]， 　　P 0.05），implicit blood loss（WMD = 0.19，95% CI = [0.11，0.28]，P 0.000 01），and volume of drainage（WMD = 0.19，95% CI = [0.08，0.31]，P = 0.001）.The differences of the following parameters before and after treatment had no statistical significance：VAS scores（WMD = -1.23，95% CI = [-2.51，-0.05]，P = 0.06），KSS scores（clinical scores WMD = -0.48，95% CI = [-1.34，0.37]，P = 0.27，function scores WMD = 0.14，95% CI = [-0.39，0.68]，P = 0.60），