瑞舒伐他汀对肥胖大鼠心肌NF―κB表达影响.docVIP

瑞舒伐他汀对肥胖大鼠心肌NF―κB表达影响 　　[摘要] 目的 研究瑞舒伐他汀对肥胖大鼠心肌核转录因子-κB（NF-κB）蛋白表达的影响，为深入探讨瑞舒伐他汀对心肌的保护机制提供依据。 方法 将30只雄性大鼠随机分成3组：正常组、肥胖组和瑞舒伐他汀干预组，分别用普通饲料、高脂饲料以及高脂饲料+瑞舒伐他汀饲养12周，分别测定各组的心脏重量、TC、TG、HDL、LDL-C、NF-κB蛋白表达和HE染色观察心肌病理组织学改变。 结果 肥胖大鼠的血清TG、TC、LDL-C、心脏重量的水平均显著高于正常组（P0.01）；瑞舒伐他汀干预可减少心肌NF-κB蛋白表达（P0.05），显著降低肥胖大鼠的血脂及改善心肌的病理组织学改变。 结论 瑞舒伐他汀在调节血脂代谢的同时可能通过NF-κB蛋白信号通路减轻了肥胖大鼠心肌组织的病理改变。 　　[关键词] 瑞舒伐他汀；肥胖大鼠；核因子-κB；心肌 　　[中图分类号] R364.2+2 [文献标识码] B [文章编号] 1673-9701（2015）01-0004-03 　　Effects of rosuvastatin on NF-κB expression in obese rats’ myocardium 　　PAN Guiqun1 SUN Dongsheng2 　　1.Department of Internal Medicine， the Third Peoples Hospital of Yuyao City in Zhejiang Province， Yuyao 315400， China； 2.Cadre Department， Zhejiang Provincial People’s Hospital， Hangzhou 310014， China 　　[Abstract] Objective To evaluate the effects of rosuvastatin on nuclear transcription factor-kB （NF-kB） protein expression in obese rat cardiac and to explore the roles of the protection of rosuvastatin about the heart. Methods Thirty male rats were divided into three groups： normal group， high -fat group and hight-fat+Rosuvastatin group. They were obtained a standard diet， high-fat diet and a high-fat+rosuvastatin diet respectively，for 12 weeks. The levels of heart weight， TC， TG， HDL， LDL-C， NF-kB protein expression， and HE staining histopathological changes of the myocardial. Results The levels of serum TG、TC、LDL-C and heart weight in obese rats were all higher than control rats（P0.01）； Rosuvastatin could effectivly reduce the levels of NF-kB （P0.05），blood lipid and induced the pathological changes in myocardial. Conclusion It demonstrates that Rosuvastatin could effectively reduce the levels of blood lipid and may with NF-kB protein pathway reduced the pathologic changes in myocardial tissue of obese rats . 　　[Key words] Rosuvastatin； Obesity rats； Nuclear factor-kB； Myocardial 　　肥胖常与高血压、动脉硬化、脂质代谢紊乱等同时出现，是心血管疾病的危险因素。其中核因子-κB（NF-κB）是一种具有多项调控作用的转录因子，激活后可调控多种炎性因子、细胞因子的表达，参与了多种心血管疾病的演变，而引起心肌的炎性反应[1]。瑞舒伐他汀是HMG-