神经元特异性烯醇化酶测定在酒精所致精神障碍中临床研究.docVIP

神经元特异性烯醇化酶测定在酒精所致精神障碍中临床研究 　　【摘要】 目的 探讨酒精所致精神障碍的脑损伤程度；评估以戒酒、促脑细胞代谢为主的治疗方案的疗效；建立酒精所致精神障碍的生化诊断指标；为药物及心理治疗提供理论依据，提高治疗效果。方法 采用酶联免疫吸附法对45例酒精所致精神障碍的患者治疗前以及治疗4周后进行血清中的NSE含量测定，并与45例正常对照组进行比较，同时对全部病例进行头颅CT检查以及BPRS和HRSD精神症状的评定。结果 病例组血清中NSE含量明显高于对照组(P0.05)，病例组治疗4周后血清NSE含量比治疗前有所降低(P0.05)，病例组的CT检查异常率93.33%,血清中NSE含量与BPRS分值(r=0.588,P0.001)、HRSD分值(r=0.581,P0.001)均呈现正相关。结论 检测血清中NSE含量，可以反映酒精所致精神障碍严重程度，评价治疗方案的疗效，还可指导临床用药。? 　　【关键词】 神经元特异性烯醇化酶；精神障碍；汉密顿抑郁量表；简明精神病量表 ?? 　　 　　The clinical research of neuron?specific endase on patients with alcoholism mental disorders 　　 　　LIU Jian?bin,YE Lan?xian,LI Bao?zhu,et al.The Second AffiliatedHospital of Lan Zhou University,LanZhou 730030,China 　　? 　　【Abstract】 Objective To explore the extent of brain damage,evaluate the curative effect of therapeutic project about temperance and the promoting metabolize of brain cell,establish the biochemistry and diagnostic index of alcoholism mental disorders,provide the academic gist of the pharmic and mental treatment,improve the therapeutic effect.Methods Serum NSE(with ELISA)levels in patients with alcoholism mental disorders(altogether 45 patients)and 45 controls,CT and the assessing of BPRS and HRSD evaluated.Results Serum NSE levels were significantly higher in patients with alcoholism mental disorders than those in the controls(P0.05),and were higher than those in same patients after the 4 weeks treatment(P0.05).The abnormal rate of the Brain CT was 93.33%.The relation of the serum NSE levels and the assessing of BPRS(r=0.588,P0.05)and HRSD(r=0.581,P0.05)were positive correlation.Conclusion The measure of serum NSE levels can response the serious degree of alcoholism mental disorders and evaluate the curative effect of therapeutic project,and instruct clinical administration.? 　　【Key words】 Neuron?specific enolase; Mental disorders; HRSD; BPRS 　　 　　神经元特异性烯醇化酶(NSE)是参与糖酵解的重要酶，特异性的存在于大脑神经元和神经内分泌细胞中，占脑内可溶性蛋白的1.5%，神经元损伤或坏死后，NSE进入脑脊液及血液，故测定患者血液中NSE含量，可了解脑损害的程度，国内外资料已有脑外伤及脑肿瘤患者NSE测定的研究，但对慢性酒精所致精神障碍尚未