米诺地尔溶液联合窄谱中波紫外线治疗头皮毛发区进展型白癜风临床观察.docVIP

米诺地尔溶液联合窄谱中波紫外线治疗头皮毛发区进展型白癜风临床观察 　　【摘要】目的探讨5%米诺地尔溶液联合窄谱中波紫外线（Narrow Bound Ultra Violet B Light；NBUVB）治疗头皮毛发区进展型白癜风的疗效。方法选择门诊就诊的129例头皮毛发区进展型白癜风患者随机分为两组，实验组65例采用5%米诺地尔溶液联合NBUVB光疗进行治疗，对照组64例单纯采用NBUVB光疗，两组患者治疗2个月为一个疗程，共治疗三个疗程，比较两组患者每个疗程结束后的疗效。结果 实验组治疗一个疗程、二个疗程、三个疗程后的疗效均显著优于对照组，差异有统计学意义（P0.05或0.01）。治疗期间两组患者均无明显的不良反应。结论5%米诺地尔溶液联合NBUVB治疗头皮毛发区进展型白癜风疗效显著，不良反应少，值得临床推广应用。 　　【关键词】白癜风；头皮；5%米诺地尔溶液；窄谱中波紫外线 　　中图分类号：R758.71 文献标识码：ADOI：10.3969/j.issn2015.04.022 　　【Abstract】ObjectiveTo investigate efficacy of 5% minoxidil solution combined with Narrow Bound Ultra Violet B Light （NBUVB） in the treatment of progressive leukoderma in scalp hair area.Methods129 outpatients with progressive leukoderma were randomly divided into two groups.65 cases in experience group were treated with 5% minoxidil solution combined with NBUVB，while 64 cases in control group were merely given NBUVB.With every two months were taken as a course of treatment，both groups were given three courses.Then，effects of both groups after each course were compared，respectively.Results Effects of the experience group after one course，two courses and three courses were obviously better than those of the control group，and the differences were statistically significant （P0.05 or 0.01）.No adverse reactions were found in both groups during the treatment.Conclusion5% minoxidil solution combined with NBUVB for progressive leukoderma in scalp hair area has an obvious efficacy with few adverse reactions.Thus，it is worthy of popularization and application in clinic. 　　【Key words】leucoderma；scalp；5% minoxidil solution；NBUVB 　　白癜风是一种由色素脱失而引起的皮肤常见病，主要表现为患处皮肤脱色。毛发区白癜风患者除皮肤脱色外，常伴有受累区毛发变白，治疗更为困难，严重影响美观，给患者带来很大的心理困扰。有关本病的发病机制目前尚未完全清楚，治疗方法多种多样，疗效也不尽相同。我院自2012年1月～2014年6月采用5%米诺地尔溶液联合NBUVB治疗65例发生在头皮毛发区进展型白癜风患者，取得较好的临床疗效，现报告如下。 　　1资料与方法1.1一般资料入选的129例患者均来自我院门诊，其中男性75例，女性54例，皮损面积（0.2×0.5） cm2～（6×7.2） cm2，皮损个数1～4个不等。按随机数字表分为两组。实验组65例，男性39例，女性26例，平均年龄（39.91±5.85）岁，皮损总数共116个，平均（1.97±0.43）个，最小皮损面积为0.2 cm×0.5 cm，最大皮损面积为6.2 cm×6.5 cm