糖尿病合并冠心病患者高敏C反应蛋白与血小板参数相关性研究.docVIP

糖尿病合并冠心病患者高敏C反应蛋白与血小板参数相关性研究 　　[摘要] 目的 探讨糖尿病合并冠心病患者高敏C反应蛋白（hs-CRP）与血小板参数的相关性及其临床意义。 方法 选择我院门诊或住院患者及健康体检者，分为糖尿病合并冠心病（DM+CHD）、冠心病（CHD）、糖尿病（DM）和对照四个组，分别检测hs-CRP及血小板计数（PLT）、平均血小板体积（MPV）、血小板压积（PCT）、大血小板比率（P-LCR）、血小板分布宽度（PDW）五项血小板参数的水平，并进行比较分析。 结果 （DM+CHD）组hs-CRP、MPV、PCT、P-LCR和PDW水平显著高于CHD、DM和对照组（P DM组CHD组（DM+CHD）组，呈降低趋势，hs-CRP、MPV、PCT、P-LCR、PDW水平：对照组DM组CHD组（DM+CHD）组，呈升高趋势。hs-CRP与PLT呈负相关（r = -0.725，P 0.05），与MPV（r = 0.801，P 0.01），PCT（r = 0.747，P 0.05），P-LCR（r = 0.713，P 0.05），PDW（r = 0.724，P 0.05）均呈正相关。 结论 hs-CRP及血小板在糖尿病合并冠心病的发生、发展过程有显著相关性，hs-CRP及血小板参数是糖尿病合并冠心病患者病情观察和评价的有用指标。 　　[关键词] 糖尿病；冠状动脉疾病；高敏C反应蛋白；血小板参数 　　[中图分类号] R587.1 [文献标识码] A [文章编号] 1673-7210（2012）02（c）-0060-03 　　 　　The correlation research of high-sensitivity C-reactive protein and platelet parameters for diabetes mellitus patients with coronary heart disease 　　ZHANG Shuzhen LU Xiulan OU Lili 　　The Kuichong People′s Hospital of Longgang District in Shenzhen City, Guangdong Province, Shenzhen 518119, China 　　[Abstract] Objective To investigate the correlation and clinical significance of hs-CRP and platelet parameters for diabetes mellitus patients with coronary heart disease. Methods Diagnosed outpatient or inpatient patients and health people were chosen and divided into four groups including (DM+CHD), CHD, DM and control group, meanwhile, hs-CRP, PLT, MPV, PCT, P-LCR, PDW were measured individually, and analyzed comparatively. Results The results of hs-CRP, MPV, PCT, P-LCR and PDW in (DM+CHD) group were significantly higher than those of CHD, DM and control group（P 0.01）, PLT count was distinguishably lower than that of CHD, DM and healthy control group (P 0.01). PLT count was decreasing by the sequence of healthy control, DM, CHD, and(DM+CHD) group, meanwhile, the results of h-CRP, MPV, PCT, P-LCR and PDW were increasing by the sequence of control, DM, CHD, and (DM+CHD) group. hs-CRP was negatively correlated with PLT (r = -0.725, P 0.05), but were positively correlated with MPV (r = 0.801, P