稳定期中重度慢阻肺患者血清IL―6IL―8TNF―αhs―CRP与肺功能相关性研究.docVIP

稳定期中重度慢阻肺患者血清IL―6IL―8TNF―αhs―CRP与肺功能相关性研究 　　[摘要] 目的 探讨血清白介素-6（IL-6）及白介素-8（IL-8）、肿瘤坏死因子α（TNF-α）、超敏C反应蛋白（hs-CRP）水平在稳定期中重度慢性阻塞性肺疾病病患中与肺功能存在的相关性。方法 2016年1月～2017年1月选取我院所收治的慢阻肺患者60例为观察组，并选取同一阶段体检结果为正常者60例，形成对照组，检测和对比两组各因子水平，测定其与肺功能FEV1%pred，血尿酸的关系。结果 观察组患者各因子水平显著高于健康对照组（P0.01），且观察组患者FEV1%显著低于对照组（P0.05），血尿酸含量显著高于对照组（P0.05），患者TNF-α、IL-6、IL-8和hs-CRP含量与 FEV1%负相关，与患者血尿酸呈正相关关系。结论 患者存在气道炎症，或许是引起患者肺功能进行性下降的因素。 　　[关键词] 慢性阻塞性肺疾病；肺功能；稳定期 　　[中图分类号] R563.9 [文献标识码] A [文章编号] 2095-0616（2017）07-228-03 　　Correlations between serum IL-6，IL-8，TNF-α，and hs-CRP levels with lung function in patients with moderate and severe chronic obstructive pulmonary disease in slationary phase 　　LAN Fang 　　Zhongshan City Banfu Hospital，Guangdong Province，Zhongshan 528459，China 　　[Abstract] Objective To discuss the correlation between serum interleukin-6（IL-6），interleukin-8（IL-8），tumor necrosisfactor α（TNF-α），hypersensitive C reactive protein（hs-CRP）levels with lung function in patients with moderate and severe chronic obstructive pulmonary disease in slationary phase. Methods 60 cases with COPD from Jan 2016 to Jan 2017 were selected as observation group，and 60 cases with healthy examination in the same phase were selected as control group.IL-6，IL-8，TNF-α，and hs-CRP of two groups were detected， and the correlation between IL-6，IL-8，TNF-α，and hs-CRP with FEV1%pred，serum uric acid were analyzed. Results IL-6，IL-8，TNF-α，and hs-CRP levels of observation group were higher than those of control group（P0.01），and FEV1% of observation group were lower than that of control group（P0.05）；Serum uric acid were higher than that of control group（P0.05）.IL-6，IL-8，TNF-α，and hs-CRP levels showed negative correlation with FEV1%，and positive correlation with serum uric acid. Conclusion Patients with moderate and severe chronic obstructive pulmonary disease in slationary phase exit airway inflammation，which maybe the cause of progressive decline in lung function. 　　[Key words] Chronic obstructive pulmonary disease；Lung