米多君联合低温可调钠对改善透析低血压临床研究.docVIP

米多君联合低温可调钠对改善透析低血压临床研究 　　[摘要] 目的 探讨透析低血压的相关症状和米多君联合低温可调钠对透析相关性低血压的治疗作用。方法 整群选取2013年3月-2014年6月在该院治疗的120例反复发生透析相关性低血压的患者，采用自身分组对照的方法随机分为常温普通钠透析组（对照组），普通钠常温+米多君组（米多君透析组），低温可调钠组（低温可调钠透析组），低温可调钠+米多君组（联合治疗透析组），每组30例，每种治疗方法应用5次透析，比较四组方法透析中平均动脉压和低血压的发生次数。结果 米多君透析组、低温可调钠透析组、联合治疗透析组平均动脉压分别为13.3%、15.3%、6.7%显著高于对照组21.3%（P0.05）。结论 使用低温可调钠透析联合米多君对透析相关性低血压临床疗效显著。 　　[关键词] 透析相关性低血压；盐酸米多君；低温；可调钠 　　[中图分类号] R [文献标识码] A [文章编号] 1674-0742（2015）11（b）-0135-03 　　[Abstract] Objective To discuss the complication of dialysis hypotension and the clinical curative effect of midodrine combined low temperature adjustable sodium for dialysis hypotension. Methods 120 patients experiencing repeated occurrence of dialysis hypotension and treated in our department from March 2013 and June 2014 were randomized to undergoing normal-temperature sodium dialysis （the control group， n=30）， dialysis using normal-temperature sodium combined with midodrine （midodrine dialysis group， n=30）， dialysis using low temperature adjustable sodium （dialysis using low temperature adjustable sodium group， n=30）， and dialysis using midodrine combined low temperature adjustable sodium （combined dialysis group， n=30）， according to self-grouping and controlled method. Each dialysis regimen was performed five times for the patients. The mean arterial blood pressure and the frequency of low blood pressure were compared between the patients in the four groups. Results The mean arterial blood pressure of the midodrine dialysis group， dialysis using low temperature adjustable sodium group， and combined dialysis group was 13.3%， 15.3%， 6.7% respectively， all significantly higher than that in the control group which was 21.3%. Conclusion The clinical curative effect of midodrine combined low temperature adjustable sodium for dialysis hypotension is remarkable. 　　[Key words] Dialysis hypotension； Midodrine hydrochloride； Low temperature； Adjustable sodium 　　透析低血压（Intradialysis hypotension，IDH）是一种常见的血液透析并发症，指透析中平均动脉压降低10 mmHg以上或收