细菌性阴道病患者阴道灌洗液中干扰素―γ和白细胞介素―4含量分析.docVIP

细菌性阴道病患者阴道灌洗液中干扰素―γ和白细胞介素―4含量分析 　　【摘要】目的：检测细菌性阴道病患者治疗前后阴道灌洗液中干扰素-γ和白细胞介素-4的含量，以分析阴道局部免疫状况和临床治疗效果。方法：通过分析2013年10月至2014年7月我院收治的47例细菌性阴道病患者的临床资料，使用酶联免疫吸附法检测患者治疗前后阴道灌洗液中干扰素-γ和白细胞介素-4的含量，同时对47例健康妇女检测结果进行对比分析。结果：BV组患者IFN-γ水平显著低于对照组健康妇女IFN-γ水平，组间差异具有统计学意义（P0.05）。统计BV患者治疗前后IFN-γ、IL-4两项水平，BV治愈患者IFN-γ较治疗前有显著提高，IL-4则显著降低，未治愈患者则呈反向变化，BV治愈患者和未治愈患者IFN-γ和IL-4水平差异显著（P0.05）。结论：BV患者患病同IFN-γ水平显著降低和Th1/Th2比例失衡存在一定的相关关系，为治疗BV提供了一定依据。 　　【关键词】细菌性阴道病；阴道灌洗液；干扰素-γ；白细胞介素-4 　　Analysis on interferon -γ and interleukin-4 levels in vaginal lavage fluid of patients with bacterial vaginosisLI Shu1， ZHAO Jumei1△， ZOU Zhenyu2. 1.Department of Obstetrics and Gynecology， Panzhihua City Second People’s Hospital， Panzhihua 617000， Sichuan， China； 2.Anesthesia Department， Panzhihua City Second People’s Hospital， Panzhihua 617000， Sichuan， China 　　【Abstract】Objectives： To detect interferon-γ and interleukin-4 levels in vaginal lavage fluid of patients with bacterial vaginosis and analyze vaginal immune status and clinical outcomes. Methods： By analyzing clinical data of 47 cases of bacterial vaginosis in our hospital from October 2013 to July 2014 and using enzyme-linked immunosorbent assay to detect interferon -γ and interleukin - 4 content， the test results were analyzed. Results： IFN-γ level in patients with BV was significantly lower than that in control group. The difference was statistically significant （P0.05）. IFN-γ level of BV cure patients after treatment significantly increased and IL-4 level significantly reduced. IFN-γ and IL-4 level of uncured patient were in opposite directions. IFN-γ and IL-4 levels of BV cured patients and uncured patients were significantly different （P0.05）. Conclusion： Significant reduced level of IFN-γ in BV patients is correlative with Th1 / Th2 imbalance， which provides a certain basis for the treatment of BV. 　　【Key words】Bacterial vaginosis； Vaginal lavage； IFN -γ； Interleukin-4 　　【中图分类号】R711.31【文献标志码】A 　　细菌性阴道病（bacterial vaginosis，BV）是指发生于阴道内的菌群失调，大量病原菌如加德