舒芬太尼和羟考酮对腹腔镜下结直肠癌根治术患者免疫功能影响.docVIP

舒芬太尼和羟考酮对腹腔镜下结直肠癌根治术患者免疫功能影响 　　【摘要】 目的：探?舒芬太尼和羟考酮对腹腔镜下结直肠癌根治术患者免疫功能的影响。方法：选取2016年2月-2017年2月在本院诊断治疗的结直肠癌患者60例。按照随机数字表法将其分为舒芬太尼组与羟考酮组，各30例。羟考酮组采用羟考酮进行麻醉诱导，舒芬太尼组采用舒芬太尼进行麻醉诱导。比较不同时间点两组CD3+、CD4+、CD8+淋巴细胞以及CD4+/CD8+、自然杀伤细胞（NK）以及B淋巴细胞水平。结果：手术结束时及术后24、48 h，两组CD4+、CD3+淋巴细胞、CD4+/CD8+、NK细胞及 　　B淋巴细胞水平均显著低于麻醉诱导前30 min（P0.05）。结论：与舒芬太尼比较，羟考酮用于腹腔镜下结直肠癌根治术的麻醉诱导对患者免疫功能的影响相对较小。 　　【关键词】 舒芬太尼； 羟考酮； 腹腔镜； 结直肠癌根治术； 免疫功能 　　Effect of Sufentanil and Oxycodone on Immune Function of Laparoscopic Resection Colorectal Cancer/GUO Xiaomeng，YANG Xiujuan.//Medical Innovation of China，2018，15（08）：119-124 　　【Abstract】 Objective：To discuss the effect of Sufentanil and Oxycodone on immune function of laparoscopic resection colorectal cancer.Method：A total of 60 patients with colorectal cancer diagnosed and treated in our hospital from February 2016 to February 2017 were selected.According to the random number table method，they were divided into Sufentanil group and Oxycodone group，30 cases in each group.Sufentanil group was induced by Sufentanil，Oxycodone group was induced by Oxycodone.The levels of CD3+，CD4+，CD8+ lymphocytes and CD4+/CD8+，natural killer cells（NK） and B lymphocytes at different time points of two groups were compared.Result：At the end of operation and after operation 24，48 h，the levels of CD4+，CD3+ lymphocytes，CD4+/CD8+，NK cells and B lymphocytes in two groups were significantly lower than those of before anesthesia induction 30 min（P0.05）.Conclusion：Compared with Sufentanil，the anesthesia induction of Oxycodone for laparoscopic radical resection of colorectal cancer has a relatively small effect on the immune function of the patients. 　　【Key words】 Sufentanil； Oxycodone； Laparoscopy； Radical resection colorectal cancer； Immune function 　　First-author’s address：First Affiliated Hospital of Jiamusi University，Jiamusi 154000，China 　　doi：10.3969/j.issn.1674-4985.2018.08.030 　　结直肠癌是消化道常见的恶性肿瘤，发病率仅次于胃癌与食管癌，发病年龄以40～70岁多见，肿瘤可发生在结肠的任何部位，结肠癌早期症状不明显，常常误诊为其他疾病。腹腔镜下结直肠癌根治术是治疗结直肠癌的主要手术方法，具