肝硬化患者检测BNP临床意义研究.docVIP

肝硬化患者检测BNP临床意义研究 　　【摘要】 目的：研究BNP检测运用在肝硬化患者中的临床意义。方法：选择2014年7月-2015年10月本院收治的57例肝硬化患者作为观察组，再选择同期本院收治的非肝硬化肝病患者60例作为对照组，分别检测两组的BNP水平，并对两组检测结果进行对比分析。结果：相比较对照组而言，观察组的BNP水平明显较高，比较差异有统计学意义（P0.05）；与Child-Push A级和B级患者相比，Child-Pugh C级患者的BNP水平明显较高，比较差异有统计学意义（P0.05），并且BNP水平与Child-Push分级呈正比关系；但是，BNP水平与血尿素氮、胱抑素C以及肌酐等呈正比关系，与纤维蛋白原、血浆凝血酶原时间等无关；同时，BNP水平与患者的生存率呈反比关系。结论：BNP水平可以将肝硬化患者的病情严重程度充分反映出来，并且受到肾功能异常、贫血以及消化道出血等因素影响。 　　【关键词】 BNP； 肝硬化； 临床意义 　　Clinical Significance of BNP Detection for Cirrhosis Patients/PENG Shuang-feng，JIANG Xu-qin，XIONG Wen-juan，et al.//Medical Innovation of China，2016，13（27）：041-044 　　【Abstract】 Objective：To research the clinical significance of BNP detection for cirrhosis patients.Method：From July 2014 to October 2015，57 cases of cirrhosis patients in our hospital were selected as the observation group，and 60 cases of other diseases patients in our hospital were selected as the control group.BNP levels in two groups were respectively detected，and detection results in two groups were compared and analyzed.Result：Compared with the control group，BNP level in the observation group was higher，the difference was statistically significant（P0.05）.Compared with the patients of Child-PushA and B，Child-Push C patient’s BNP level was higher，the difference was statistically significant（P0.05）.BNP level was positive with Child-Push class，but BNP level was positive with blood urea nitrogen，creatinine and cystatin C，and unrelated with fibrinogen and prothrombin time.At the same time，BNP level and survival was inversely proportional.Conclusion：BNP level can fully reflect the disease of cirrhosis patients，and is affected by the indicators of renal dysfunction，anemia and gastrointestinal bleeding. 　　【Key words】 BNP； Cirrhosis； Clinical significance 　　First-author’s address：The People’s Hospital of Guixi City，Guixi 335400，China 　　doi：10.3969/j.issn.1674-4985.2016.27.011 　　肝硬化是一种临床常见的慢性肝病，随着肝纤维化的不断进展，肝脏结构及血流循环途径的改建，门脉高压症的发生，随之继发神经内分泌及血流动力学改变，比较突出的是肾素-血管紧张素-醛固酮系统（RAAS）过度激活及交