肺癌合并肺部真菌感染研究进展.docVIP

肺癌合并肺部真菌感染研究进展 　　【摘要】 目的 探讨肺癌患者肺部真菌感染的病因、诊断、治疗及预防。方法 对50例肺癌合并肺部真菌感染患者的病因、临床表现、治疗等做回顾性分析。结果 肺癌患者合并肺部真菌感染与长期应用抗生素、细胞毒性药物以及机体免疫力低下有关。50例肺癌合并肺部真菌感染患者中， 25例应用氟康唑， 4例应用伊曲霉唑后病情好转， 21例并发难以控制的肺部感染而死亡， 肺癌并发肺部真菌感染患者病死率为42.0%， 明显高于普通细菌感染患者的7.5%。50例的真菌培养均阳性， 其中白色念珠菌38例， 酵母样菌6例， 热带念珠菌6例。结论 对于肺癌合并肺部真菌感染的患者应注意早期预防、早期诊断、及时诊治， 同时选择合适的抗真菌药物， 并提高机体的免疫力及支持治疗， 才能达到满意的效果。 　　【关键词】 肺癌；肺部真菌感染；治疗 　　DOI：10.14163/j.cnki.11-5547/r.2015.26.017 　　Research progress of lung cancer complicated with pulmonary fungal infection YANG Dan， LIU Shi-lin. Department of Emergency， Jinzhou City Central Hospital， Jinzhou 121000， China 　　【Abstract】 Objective To investigate pathogenesis， diagnosis， treatment， and prevention of pulmonary fungal infection in lung cancer patients. Methods A retrospective analysis was made on pathogenesis， clinical manifestations， and treatment of 50 lung cancer complicated with pulmonary fungal infection patients. Results Lung cancer complicated with pulmonary fungal infection had correlation with long-term antibiotics administration， cytotoxic drug， and low immunity. Among the 50 lung cancer complicated with pulmonary fungal infection patients， there were 25 relieved cases receiving fluconazole， 4 cases receiving itraconazole， and 21 death cases due to complicated unmanageable pulmonary infection. Mortality of lung cancer complicated with pulmonary fungal infection patients was 42.0%， which was much higher than 7.5% of common bacterial infection patients. All the 50 cases had positive fungal culture. Among them， there were 38 candida albicans cases， 6 saccharomycopsis cases， and 6 candida tropicalis cases. Conclusion Early prevention， diagnosis and treatment are necessary for lung cancer complicated with pulmonary fungal infection patients. Choice of appropriate antifungal drug， immunity improvement， and support therapy can provide satisfactory effect. 　　【Key words】 Lung cancer； Pulmonary fungal infection； Treatment 　　目前， 肺癌的收治率提高与肺癌发病率的上升呈正相关， 在机体免疫力低下时， 由于肿瘤的侵入与损伤、气道的阻塞及长