羟苯磺酸钙对高血压早期肾损害影响.docVIP

羟苯磺酸钙对高血压早期肾损害影响 　　[摘要] 目的 研究羟苯磺酸钙对高血压早期肾损害的影响。 方法 纳入2014年1～10月在青岛市海慈医疗集团肾病科住院且诊断为高血压肾病的患者40例，将其随机分为对照组（n = 20）和治疗组（n = 20）。两组患者均用缬沙坦或厄贝沙坦将血压降至正常范围。治疗组在常规治疗的基础上给予羟苯磺酸钙口服，观察8周。分别于治疗前后检测患者血肌酐和24 h尿微量白蛋白。 结果 两组治疗前后血肌酐水平，组内及组间比较差异均无统计学意义（P 0.05）。对照组24 h尿微量白蛋白由治疗前的（125.37±57.36）mg/24 h降至治疗后的（120.57±53.82）mg/24 h，治疗组24 h尿微量白蛋白由治疗前的（127.69±57.22）mg/24 h降至治疗后的（87.91±40.65）mg/24 h，两组组内治疗前后比较差异均有统计学意义（P 0.05），且治疗组治疗后24 h尿微量白蛋白显著低于对照组，差异有高度统计学意义（P 0.01）。 结论 羟苯磺酸钙降低高血压患者24 h尿微量白蛋白效果优于常规治疗方法，具有肾脏保护作用。 　　[关键词] 高血压；早期肾损害；尿微量白蛋白；羟苯磺酸钙 　　[中图分类号] R544.1；R692.3 [文献标识码] A [文章编号] 1673-7210（2016）01（a）-0126-04 　　Effect of Calcium Dobesilate on early renal damage in hypertension 　　WANG Xuechun1 LIU Xianying2 LIU Ling3 　　1.Weifang Medical University， Shandong Province， Weifang 261000， China； 2.Department of Nephrology， Hiser Medical Center， Shandong Province， Qingdao 266000， China； 3.Department of Burn and Plastic Surgery， Affiliated Hospital of Zunyi Medical College， Guizhou Province， Zunyi 563000， China 　　[Abstract] Objective To study the effect of Calcium Dobesilate on early renal damage in hypertension. Methods A total of 40 cases of patients diagnosed as hypertensive nephropathy hospitalized in Department of Nephrology of Hiser Medical Center from January to October 2014 were enrolled and randomly divided into control group （n = 20） and treatment group （n = 20）. Both groups were given Valsartan or Irbesartan to reduce blood pressure to a normal range. On basis of conventional therapy， the treatment group was given Calcium Dobesilate orally， observation for 8 weeks. The levels of serum creatinine and 24 h urine microalbumin before and after treatment were measured respectively. Results There were no statistically significant differences of serum creatinine before and after treatment within the two groups and between two groups （P 0.05）. The level of 24 h urine microalbumin of control group was descended from （125.37±57.36） mg/24 h before treatment to （120.57±53.82） mg/24 h a