肿瘤标志物CEACYFRA21―1和TPS联合检测在老年非小细胞肺癌中诊断价值.docVIP

肿瘤标志物CEACYFRA21―1和TPS联合检测在老年非小细胞肺癌中诊断价值 　　【摘要】 目的：评价肿瘤标志物CEA、CYFRA21-1和TPS联合检测在老年非小细胞肺癌中的诊断价值。方法：选取2013年1月-2017年1月本院确诊的老年非小细胞肺癌（NSCLC）患者150例作为研究对象，纳入NSCLC组，另选同期收治的肺部良性病变患者71例纳入良性组，健康体检者80例纳入对照组，三组均进行采血，采用化学发光微粒子免疫分析法以及配套试剂检测CEA、CYFRA21-1、TPS，并进行对比，评价诊断效用。结果：对照组CEA、CYFRA21-1、TPS水平均低于良性组，良性组均低于NSCLC组，差异均有统计学意义（P0.05）；TPS、CEA+CYFRA21-1+TPS检测敏感度、阳性预测值、阴性预测值、符合率均高于CEA、CYFRA21-1（P0.05），CEA+CYFRA21-1+TPS检测敏感度、特异度、阳性预测值、阴性预测值、符合率分别为96.00%、96.03%、96.00%、96.03%、96.01%均高于TPS诊断的91.33%、90.07%、90.13%、91.28%、90.70%，差异均有统计学意义（P0.05）。结论：肿瘤标志物CEA、CYFRA21-1和TPS联合检测应用于老年NSCLC，有助于提高诊断效用。 　　【关键词】 老年人； 非小细胞肺癌； 肿瘤标志物； 诊断 　　The Diagnostic Value of Tumor Markers CEA，CYFRA21-1 and TPS Joint Detection in Senile Non-small Cell Lung Cancer/DU Zhen-yuan.//Medical Innovation of China，2017，14（30）：004-007 　　【Abstract】 Objective：To evaluate the diagnostic value of tumor markers CEA，CYFRA21-1 and TPS joint detection in senile non-small cell lung cancer（NSCLC）.Method：150 cases of senile NSCLC confirmed by the hospital from January 2013 to January 2017 were selected as the study subjects and included in NSCLC group，at the same time，71 cases of benign pulmonary diseases were enrolled in benign group，80 cases of healthy check-up as the control group.They were given the chemiluminescence microparticle immunoassay and auxiliary reagent for detection of CEA，CYFRA21-1 and TPS，and diagnostic utility was evaluated.Result：The CEA，CYFRA21-1，TPS levels of control group were lower than those of benign group，and the benign group were lower than those of NSCLC group，the differences were significant statistically（P0.05）.TPS，CEA+CYFRA21-1+TPS detection sensitivity，positive predictive value，negative predictive value and coincidence rate were higher than those of CEA，CYFRA21-1（P0.05），CEA+CYFRA21-1+TPS detection sensitivity，specificity，positive predictive value，negative predictive value，coincidence rate were 96.00%，96.03%，96.00%，96.03%，96.01% respectively，which higher than 91.33%，90.07%，90.13%，91.28%，90.70% of TPS di