胃癌组织SurvivinCOX2Ki67表达及意义.docVIP

胃癌组织SurvivinCOX2Ki67表达及意义 　　[摘要] 目的：探讨胃癌组织中凋亡抑制蛋白（Survivin）、环氧合酶-2（COX-2）及核增殖抗原（Ki67）的表达与生物学特性的关系。方法：采用免疫组织化学染色（S-P）法检测58例胃癌标本Survivin、COX-2及Ki67的表达，并以58例正常胃黏膜作为对照组。结果：胃癌组织中Survivin及COX-2表达率分别为79.31%和82.76%，均高于正常胃黏膜（P＜0.01）；Survivin及COX-2的表达与胃癌性别、年龄、部位及大小无相关性（P＞0.05），而与胃癌的浸润深度、淋巴结转移及TNM分期有关（P＜0.05），且二者有相关性（P＜0.05，r=0.443）。Survivin及COX-2表达阳性组与阴性组比较，Ki67的表达差异有统计学意义（P＜0.01）。结论：Survivin、COX-2及Ki67在胃癌的发生、发展中起着重要作用，可作为反映胃癌生物学行为的指标。 　　[关键词] 胃癌；Survivin；COX-2；Ki67；免疫组织化学染色 　　[中图分类号] R735.2[文献标识码]A [文章编号]1673-7210（2009）02（a）-017-03 　　 　　The clinical significance and expression of Survivin, COX-2 and Ki67 in gastric carcinoma 　　HAO Wang-sheng, ZHANG Dong, HOU Pei-zhen 　　(The First Affiliated Hospital of Baotou Medical College, Baotou014010, China) 　　[Abstract] Objective: To explore the expression of Survivin, COX-2 and Ki67 in gastric carcinoma and their relationship with biological characteristics. Methods: The expression of Survivin, COX-2 and Ki67 in the tumor tissues from 58 cases of gastric carcinoma was examined by immunohistochemical S-P method，and 58 cases of normal gastric mucosa served as control group. Results: The positive rates of Survivin and COX-2 were 79.31% and 82.76% respectively, higher than those of the control group (P0.05), but were correlated with the depth of tumor infiltration (P0.05), and the extent of lymph node metastasis (P0.05) and TNM stage of cancer (P0.05). The expressions of Survivin and COX-2 had correlation in gastric carcinoma （P0.05, r=0.443）. Ki67 expression had statistical significance between Survivin and COX-2 positive expression group and negative expression group (P0.01). Conclusion: Our results suggested that Survivin, COX-2 and Ki67 play an important role in the genesis and development of gastric carcinoma, which could be the index of prognostic evaluation and determination of gastric carcinoma biological behavior. 　　[Key words] Gastric cancer; Survivin; COX-2; Ki67; Immunohistochemistry 　　 　　胃癌是最常见的恶性肿瘤之一，研究有关胃癌诊断、转移及