胃癌组织中VEGF和ILK表达及意义.docVIP

胃癌组织中VEGF和ILK表达及意义 　　[摘要] 目的 探讨胃癌组织中血管内皮生长因子（VEGF）和整合素连接激酶（ILK）的表达及其与临床病理特征的关系。 方法 应用免疫组化SABC法检测48例胃癌组织中VEGF和ILK的表达情况，利用SPSS 19.0统计软件分析VEGF和ILK的差异性及相关性。 结果 VEGF和ILK在胃癌组织中的表达阳性率依次为56.2%（27/48）、37.5%（18/48）。随着肿瘤浸润深度加深及出现淋巴结转移，两者的阳性表达率明显升高（P0.05）。VEGF和ILK在胃癌组织中的表达呈正相关（r=0.379，P0.05）。 结论 VEGF和ILK的持续递增式表达提示其可能参与了胃癌的生长、侵袭和转移过程。VEGF和ILK在胃癌中的表达存在正相关，ILK可能通过信号转导途径启动VEGF的表达，促进肿瘤早期的血管发生和形成。 　　[关键词] 胃癌；血管内皮生长因子；整合素连接激酶 　　[中图分类号] R735.2 [文献标识码] A [文章编号] 1674-4721（2015）07（b）-0047-03 　　[Abstract] Objective To explore the expressions of vascular endothelial growth factor （VEGF） and integrin-linked kinase （ILK） in gastric cancer tissue and their relationships with clinicopathological features. Methods Expressions of VEGF and ILK from gastric cancer tissue in 48 patients were detected by immunohistochemical strept avidin-biotin complex （SABC）.The difference and correlation between VEGF and ILK were analyzed by SPSS 19.0 statistical software. Results The positive expression rates of VEGF and ILK in gastric cancer tissue were 56.2% （27/48） and 37.5% （18/48） respectively.With deepening of depth of tumor invasion and lymphatic metastasis，the positive expression rates in the two indexes were greatly increased （P0.05）.Expression of VEGF had a positive correlation with ILK one （r=0.379，P0.05）. Conclusion The continuous incremental expressions of VEGF and ILK indicate that they may participate in the growth，invasion，and metastasis.VEGF has a positive correlation with ILK in the expression in gastric cancer patients.Expression of VEGF is activated by signal transduction pathway in ILK which promotes early angiogenesis and formation in tumor. 　　[Key words] Gastric cancer；Vascular endothelial growth factor；Integrin-linked kinase 　　肿瘤组织中血管的生成是肿瘤生长、发生的主要因素，而恶性肿瘤微血管网的早期建立及快速生长是其快速侵袭和发展的原因。血管内皮生长因子（vascular endothelial growth factor，VEGF）是迄今发现的最重要的促血管生成因子[1]。整合素连接激酶（integrin-linked kinase，ILK）可以介导细胞外基质蛋白的信号传递，参与了贴壁细胞的生长、增殖、移行，在肿瘤组织中高表达，抑制其活性能减弱肿瘤的侵袭和血管生成。本文通过研究胃癌中VEGF和ILK的表达，探讨它们在肿瘤的生长过程中对血管