胸腺五肽联合常规抗结核方案治疗初治菌阳肺结核疗效及对患者免疫功能干预探讨.docVIP

胸腺五肽联合常规抗结核方案治疗初治菌阳肺结核疗效及对患者免疫功能干预探讨 　　摘要：目的 探讨胸腺五肽联合常规抗结核方案在治疗初治菌阳肺结核患者的疗效及对免疫功能的治疗效果及临床意义。方法 随机选取我院2014年3月～2015年3月收治的初治菌阳肺结核患者共计72例，分为常规治疗组（对照组）和常规治疗与胸腺五肽联合治疗组（观察组），对患者的肺呼吸能力及免疫功能进行检测，同时进行细胞因子检查辅助判断治疗效果。结果 与常规治疗组相比，通过胸腺五肽联合治疗后患者肺呼吸能力和T细胞亚群数量均显著升高（P0.05）。结论 胸腺五肽联合常规抗结核方案可提高患者呼吸功能及免疫功能，在一定程度上促进病灶吸收。 　　关键词：胸腺五肽；初治菌阳肺结核；免疫功能；临床价值 　　Efficacy of Thymus Five Peptide Combined with Conventional Anti Tuberculosis Program in the Treatment of Tuberculosis of Primary Treatment and Its Effect on Immune Function in Patients 　　GE Chang-hua，GE Long，ZHANG Li-mao 　　（Department of Tuberculosis，Xuzhou Infectious Disease Hospital，Xuzhou 221004，Jiangsu，China） 　　Abstract：Objective To investigate the curative effect of recurrent bacterial Yang tuberculosis treated with Thymopentin combined with routine anti-tuberculosis scheme，and the study on the immune function and clinical significance.Methods From March in 2014 to March in 2015，72 cases of the initial treatment bacterial Yang pulmonary tuberculosis patients were randomly selected from our hospital and were divided into the conventional treatment group（control group）and combining routine treatment with thymopentin treatment group（observation group）.The lung breath ability and immune function of the patients were detected，and simultaneously the therapeutic effects were auxiliary judged with cytokines check.Results Compared with the conventional treatment group，pulmonary respiratory capacity and the number of T cells for the patients were significantly increased（P0.05）after treated with thymopentin joint.Conclusion The combination of thymopentin and the routine anti-tuberculosis solution treatment can absorb lesions and relieve pain to some extent，improve the patients respiratory function and immune function. 　　Key words：Thymopentin；Initial treatment of positive tuberculosis；Immune function；Clinical value 　　肺结核作为主要的慢性传染性肺疾，主要由结核杆菌感染引发。由于结核杆菌的形态多变和免疫抵抗性，到目前为止仍然找不到较好的治疗方法，因此，为寻找较好的治疗方案，且因为肺结核患者是因机体免疫功能低下而感染结核菌，所以本研究在常规治疗基础上联合使用胸腺五