艾拉莫德、吡咯烷二硫代氨基甲酸盐单用和联合治疗恶病质-外科学(普通外科学)专业论文.docxVIP

PAGE PAGE 6 terminal body weight. To 16 days, B the weight of the mice to the tumor volume decreased 77.6% (P 0.01), C, D, E to three groups of treated mice increased tumor weight (P 0.05). PDTC can inhibit tumor growth (P 0.05). Food intake between the groups was no statistical difference (P 0.05).. left weight of gastrocnemius muscle C, D, E group were higher than the weight of the left gastrocnemius B group (P 0.05), while C, D, E gastrocnemius weight difference between groups was not significant (P 0.05). Biochemistry detection Mice in each group before and after treatment no significant difference in serum total protein (P 0.05). Compared with the healthy group A, B, and serum albumin and blood glucose levels decreased significantly (P 0.01), triglyceride levels increased (P 0.05). 7 days after treatment, the treatment group serum albumin levels rise, but the difference was not statistically significant (P 0.05). C, D blood glucose levels higher than the B group (P 0.05), triglyceride levels decreased (P 0.05); combined treatment group blood glucose levels were significantly higher than the E group B, C group (P 0.05), but and triglyceride levels are elevated; C, D serum albumin, blood glucose and triglyceride levels showed no statistically significant (P 0.05). . Serum cytokines Not detected in normal mouse serum IL-6 activity. B tumor-bearing mice IL-6 and serum TNF-α levels were significantly increased (P 0.05). Given 7 days after treatment, C, D, E serum levels of serum IL-6 and TNF-α levels decreased compared with group B (P 0.05), E group were better than the level of IL-6 C, D group (P 0.05), TNF-α levels than D group (P 0.05); C, D, E groups of serum IL-6 and TNF-α levels was no significant difference (P 0.05) 6 Expression of NF-KB C, D, E groups can inhibit the expression of NF-κBp65 and cachexia group significantly increased nuclear translocation of p65. Among the most significant inhibitory effect of E group, and in the cachexia group had signi