胃癌时辰化疗初步临床研究.docVIP

胃癌时辰化疗初步临床研究 　　[摘要] 目的:比较顺铂联合氟尿嘧啶、亚叶酸钙时辰化疗方案与常规化疗方案治疗进展期胃癌的临床疗效及不良反应。方法:将62例胃癌患者随机分为时辰化疗组(32例)和对照组(30例),两组均采用顺铂联合氟尿嘧啶、亚叶酸钙方案治疗。结果:时辰化疗组与常规化疗组的有效率分别为53.1%、37.5%,两组比较差异有统计学意义(P0.05);不良反应发生率分别为34.4%、56.7%,两组比较差异有统计学意义(P0.05)。结论:顺铂联合氟尿嘧啶时辰化疗方案治疗进展期胃癌疗效显著,毒性反应降低,患者的生活质量得以提高。 　　[关键词] 胃癌;顺铂;氟尿嘧啶;时辰化疗 　　[中图分类号] R735.2[文献标识码]A [文章编号]1673-7210(2010)03(c)-047-02 　　 　　Clinical study of chronomodulated chemotheraphy in gastric cancer 　　Guzalnur?Niyaz, YANG Lei*, WANG Xudong 　　(Tumor Hospital of Gansu Province, Lanzhou 730050, China) 　　[Abstract] Objective: To compare clinical efficacy the chronomodulated chemotheraphy (Cisplatin combined with Fluorouracil, Leucovorin) and conventional chemotherapy in the treatment of advanced gastric cancer. Methods: 62 cases of patients with gastric cancer were randomly divided into chronomodulated chemotheraphy group (32 cases) and control group (30 cases), the two groups used the chemotherapy which was Cisplatin combined with Fluorouracil and leucovorin. Results: The effective rate of the chronomodulated chemotheraphy group and the conventional chemotherapy group was 53.1%, 37.5% respectively, there was a significant difference (P0.05), adverse reaction rate was 34.4%, 56.7%, there was a significant difference (P0.05). Conclusion: The chronomodulated chemotherapy of Cisplatin combined with Fluorouracil in the treatment of advanced gastric cancer, the effect is significant, and the toxicity is reduced, quality of life is improved. 　　[Key words] Gastric cancer; Cisplatin; Fluorouracil; Chrono-chemotherapy 　　 　　胃癌是我国最常见的恶性肿瘤之一,我省属于胃癌高发区之一。根治术是治愈该类肿瘤的主要手段,但胃癌患者大多数发现时已为不可治愈的晚期,可手术者仍有部分病例术后复发并发生转移,其平均生存期仅6～9月,而化疗是进展期胃癌治疗的主要手段,它能有效控制晚期胃癌的症状,延长生存时间。时辰化疗选择化疗药物毒性最小的时间点给药,将高浓度化疗药物注入患者体内,以达到疗效最佳、毒性最小,同时改善患者生存质量的目的。本研究对2003年12月～2009年6月62例进展期胃癌患者分别采用顺铂联合氟尿嘧啶时辰化疗和常规化疗进行对比,现将结果报道如下: 　　1 资料与方法 　　1.1 一般资料 　　62例患者均经病理组织学及细胞学确诊,已失去手术或不愿手术的进展期胃癌初治患者,Kamofsky评分≥60分,有可测量病灶,预计生存期3个月。将患者随机分为时辰化疗组和对照组,其中,时辰化疗组32例,男21例,女11例,年龄39～70岁,平均57岁;对照组30例,男19例,女11