肝癌肝动脉化疗栓塞联合碘粒子植入临床效果分析.docVIP

肝癌肝动脉化疗栓塞联合碘粒子植入临床效果分析 　　【摘要】 目的 观察分析肝动脉化疗栓塞（TACE）联合碘125（125I）粒子植入治疗肝癌的临床效果。 　　方法 70例肝癌患者， 按照治疗方法不同分为A组和B组， 每组35例。A组患者采用TACE治疗， B组患者采用TACE联合125I粒子植入治疗。比较两组患者治疗效果、6个月远处转移率及3年生存率。 　　结果 A组完全缓解8例、部分缓解16例、稳定9例、进展2例， 总有效率为68.57%;B组完全缓解13例、部分缓解19例、稳定2例、进展1例， 总有效率为91.43%;B组治疗总有效率明显高于A组， 差异具有统计学意义（χ2=5.714， Plt;0.05）。B组患者术后6个月远处转移率为5.71%， 明显低于A组的22.86%， 差异具有统计学意义（χ2=4.200， Plt;0.05）;B组患者3年生存率??31.43%， 明显高于A组的11.43%， 差异具有统计学意义（χ2=4.158， Plt;0.05）。结论 TACE联合125I粒子植入治疗肝癌能够有效降低病灶转移率， 提高生存率， 具有非常显著的临床疗效。 　　【关键词】 肝动脉化疗栓塞;碘125粒子植入;肝癌;临床疗效 　　DOI：10.14163/j.cnki.11-5547/r.2018.03.005 　　【Abstract】 Objective To observe and analyze the clinical effect of hepatic artery chemoembolization （TACE） combined with iodine 125 （125I） particle implantation for the treatment liver cancer. Methods A total of 70 liver cancer patients were divided by different treatment methods into group A and group B， with 35 cases in each group. Group A was treated with TACE， and group B was treated with TACE combined with 125I particle implantation. Comparison were made on treatment effect， 6-month distant metastasis rate and 3-year survival rate between two groups. Results Group A had 8 complete remission cases， 16 partial remission cases， 9 stable cases and 2 progressive cases， with total effective rate as 68.57%， while group B had 13 complete remission cases， 19 partial remission cases， 2 stable cases and 1 progressive case， with total effective rate as 91.43%. Group B had obviously higher total treatment effective rate than group A， and the difference was statistically significant （χ2=5.714， Plt;0.05）. Group B had obviously lower 6-month distant metastasis rate after operation as 5.71% than 22.86% in group A， and the difference was statistically significant （χ2=4.200， P， lt;0.05）. Group B had obviously higher 3-year survival rate as 31.43% than 11.43% in group A， and the difference was statistically significant （χ2=4.158， Plt;0.05）. Conclusion Combination of TACE and 125I particle implantation in treati