胃癌病理特点.docVIP

胃癌病理特点 　　[摘要] 目的：观察48例胃癌的好发部位、肉眼形态，大小及组织学类型，探讨其临床病理特点。方法：取胃壁肿瘤全层，癌旁黏膜及小于3 cm的病灶进行固定、包埋、组织切片、HE染色及组织学检查。结果：癌肿部位以胃窦部最多，占70.8%，肉眼形态以溃疡型最多，占79.2%(含局限溃疡型和浸润溃疡型)。小于3 cm的病灶大多为早期癌。结论：组织学类型与浸润深度及转移密切相关，并且随着肿瘤的进展，肿瘤细胞分化越来越差，浸润及转移率越来越高。胃癌与肠化生关系密切。 　　[关键词] 胃癌；病理特点 　　[中图分类号]R361[文献标识码]C [文章编号]1673-7210（2007）09（c）-146-02 　　 　　Study on pathological character of gastric carcinoma 　　BA Ya-ping 　　(Department of Pathology Medicine,Women and Children Medical Care Center of Luoyang,Luoyang 471000,China) 　　[Abstract] Objective：To explore the pathological character of gastric carcinoma by observing predilection site,morphology and histolgical type in 48 samples.Methods: The samples were obtained from the whole layer of diseased regions，the mucosa around the tumor and lesions that were less than 3 cm.The samples were treated by fixation, embedding, section and HE staining for histology examination.Results:The mostly occurred site of carcinoma was the gastric antrum(70.8%)，the majority types of gross examination was ulcerative type (79.2% )（infiltrative ulcerative type and localized ulcerative type were included).The tumor which was smaller than 3 cm was mostly at its early stage .Conclusion: The histological type closely relates with the infiltration and metastasis of gastric cancer. Rate of infiltration and metastasis increases with tumor progression rate.Gastric carcinoma closely relates with intestinal metaplasia. 　　[Key words] Gastric carcinoma； Patholgical character 　　 　　胃癌是我国最常见的肿瘤之一，死亡的直接原因主要是肿瘤的扩散和转移，在胃癌的防治工作中，早发现早诊断早治疗是极为重要的措施。为此，我们对48例胃癌的临床病理资料进行观察分析，旨在探讨各期胃癌的病理特点，提高诊断率。 　　 　　1 资料和方法 　　 　　资料为我院2000～2004年间病理证实为胃癌的患者48例，其中男性29例，女性19例，年龄25～76岁，平均60.4岁。术前临床诊断胃癌者42例，可疑癌变者1例，良性溃疡5例。 　　 　　2 结果 　　 　　2.1 肉眼观察 　　癌肿部位以胃窦部最多，为34例，占70.8%；依次为贲门部5例，占10.4%；胃体部4例，占8.35%；广泛性3例，占6.3%。类型以溃疡型最多（含局限溃疡型和浸润溃疡型）38例，占79.2%；蕈伞型（含盘状蕈伞型和结节蕈伞型）7例，占14.6%；弥漫浸润型3例，占6.3%。大于4 cm者42例，占87.5%;小于3 cm者6例，占12.5%. 　　2.2 组织学类型 　　以管状腺癌最多17例，占35.4%；依次为低分化腺癌15例，占31.35%； 黏液腺癌12例，占25.0%，其中2例为印戒细胞癌；未分化癌3例