美沙拉嗪联合双歧杆菌三联活菌胶囊治疗溃疡性结肠炎及对患者血清hs―CRPESRPLTD―二聚体影响.docVIP

美沙拉嗪联合双歧杆菌三联活菌胶囊治疗溃疡性结肠炎及对患者血清hs―CRPESRPLTD―二聚体影响 　　【摘要】 目的：探?美沙拉嗪联合双歧杆菌三联活菌胶囊治疗溃疡性结肠炎的效果及对患者血清超敏C反应蛋白（hypersensitive c-reactive protein，hs-CRP）、血沉（erythrocyte sedimentation rate，ESR）、血小板（blood platelet，PLT）和D-二聚体（D-dimer，D-D）的影响。方法：选取2015年1月-2017年9月本院诊治的溃疡性结肠炎患者84例，按照随机数字表法分为对照组和观察组，各42例。对照组单用美沙拉嗪治疗，观察组在对照组基础上联合双歧杆菌三联活菌胶囊治疗，均治疗8周。比较治疗前后炎性指标（hs-CRP、ESR）及血液流变学指标（PLT、D-D）改善情况，比较两组临床疗效。结果：治疗后，观察组hs-CRP、ESR水平均低于对照组（P0.05），观察组PLT、D-D水平均低于对照组（P0.05）；观察组总有效率92.86%（39/42），高于对照组的76.19%（32/42），比较差异有统计学意义（P0.05）。 　　结论：美沙拉嗪联合双歧杆菌三联活菌胶囊治疗溃疡性结肠炎效果显著，可更好地改善肠黏膜炎症反应，改善高凝状态，值得推广。 　　【关键词】 美沙拉嗪； 双歧杆菌三联活菌胶囊； 溃疡性结肠炎； 炎性指标； 高凝状态 　　Efficacy of Mesalazine Combined with Bifidobacterium Triple Viable Capsule in Treatment of Ulcerative Colitis and Its Influence on Serum hs-CRP，ESR，PLT and D-dimer/ZHAO Jing，YI Jing.//Medical Innovation of China，2017，14（35）：114-117 　　【Abstract】 Objective：To investigate the effect of Mesalazine combined with Bifidobacterium Triple Viable Capsule in treatment of ulcerative colitis and its influence on serum hypersensitive c-reactive protein（hs-CRP），erythrocyte sedimentation rate（ESR），blood platelet（PLT） and D-dimer（D-D）.Method：A total of 84 patients with ulcerative colitis in our hospital from January 2015 to September 2017 were selected，according to the random number table method，they were divided into control group and observation group，42 cases in each group.The control group was treated with Mesalazine，and the observation group was treated with Bifidobacterium Triple Active Bacteria Capsule on basis of the control group，they were treated for 8 weeks.The improvement of inflammatory indexes（hs-CRP，ESR） and hemorheology indexes（PLT，D-D） before and after treatment of two groups were compared，and the clinical efficacy of two groups was compared.Result：After treatment，the levels of hs-CRP and ESR in the observation group were lower than those of the control group（P0.05），the levels of PLT and D-D in the observation group were lower than those of the control gro