脂蛋白磷脂酶A2活性与妊娠期糖尿病及妊娠结局相关性分析.docVIP

脂蛋白磷脂酶A2活性与妊娠期糖尿病及妊娠结局相关性分析 　　[摘要]目的 探讨脂蛋白磷脂酶A2（Lp-PLA2）活性与妊娠期糖尿病（GDM）及妊娠结局的相关性。方法 选取2013年1月～2014年1月在我院分娩的150例孕产妇为研究对象，其中正常对照组50例，GDM者100例，根据血糖控制情况分为控制良好组50例和控制不良组50例。对比三组孕妇的外周血Lp-PLA2活性，并对妊娠结局状况进行统计分析。结果 血糖控制不良组患者的外周血Lp-PLA2活性显著高于血糖控制良好组和对照组（P0.05）；多因素回归分析显示，孕周、是否合并GDM与Lp-PLA2活性并无显著相关，血糖控制情况与Lp-PLA2活性有显著相关；妊娠结局对比显示，血糖控制不良组的总体不良妊娠结局显著高于血糖控制良好组和对照组（P0.05），血糖控制不良组和血糖控制良好组在早产、胎膜早破发生率上均显著高于对照组（P0.05），且血糖控制不良组早产发生率高于血糖控制良好组（P0.05）。结论 GDM孕妇的血糖控制情况与Lp-PLA2活性有显著相关，血糖控制不良孕妇的Lp-PLA2活性显著增高，且不良妊娠结局发生率升高，提示Lp-PLA2活性可能与GDM血管病变发生有所相关。 　　[关键词]妊娠期糖尿病；血糖控制；妊娠结局；脂蛋白磷脂酶A2活性 　　[中图分类号] R714.256 [文献标识码] A [文章编号] 1674-4721（2016）07（a）-0109-03 　　[Abstract]Objective To explore the relationship between the activity of lipoprotein phospholipase A2 （Lp-PLA2） and gestational diabetes mellitus （GDM） and pregnancy outcome.Methods Altogether 150 pregnant women who gave birth in our hospital from January 2013 to January 2014 were selected as research object and divided into three groups，including 50 cases healthy in control group，each 50 cases of GDM in good glycemic control group and poor glycemic control group according to blood glucose control.The peripheral blood Lp-PLA2 activity of pregnant women in three groups was compared and the statistics on the state of pregnancy outcomes were analyzed.Results The activity of peripheral blood Lp-PLA2 in poor glycemic control group was significantly higher than that of good glycemic control group and control group （P0.05）.Multivariate regression analysis showed that there was no significant correlation between the gestational weeks，whether combination with GDM and Lp-PLA2 activity；while，the control of blood glucose and Lp-PLA2 activity were significantly related to pregnancy outcome.Through comparison of pregnancy outcomes in three groups，the overall adverse pregnancy outcome of poor glycemic control group was significantly higher than that of good glycemic control group and control group （P 　　[Key words]Gestational diabetes mellitus；Glycemic control；