血管内皮细胞生长因子936CT基因多态性与结直肠癌发病风险相关性Meta分析.docVIP

血管内皮细胞生长因子936CT基因多态性与结直肠癌发病风险相关性Meta分析 　　[摘要]目的 探?血管内皮生长因子（vascular endothelial growth factor，VEGF）+936C/T基因多态性与结直肠癌（colorectal cancer，CRC）发病风险的相关性。方法 检索PubMed、EMBase和MEDLINE数据库，检索时间截止至2016年10月，应用Review Manager 4.2和Stata 11软件进行全面的Meta分析。结果 最终10篇病例对照研究文章纳入分析，包含疾病组2860例和健康对照组3080例。计算和比较各组OR值及95%CI，分析VEGF+936C/T基因多态性与CRC发病风险之间的相关性，并基于种族进行亚组分析。合并分析结果表明，在所有模型中，即T vs. C模型[OR=1.04，95%CI（0.87，1.25），P=0.63]，CT+TT vs. CC模型[OR=1.06，95%CI（0.86，1.30），P=0.61]，TT vs. CC+CT模型[OR=1.10，95%CI（0.85，1.41），P=0.47]，和TT vs. CC模型[OR=1.17，95%CI（0.91，1.52），P=0.22]，VEGF+936C/T多态性与CRC发病风险之间均无显著相关性。在欧洲人群和亚洲人群中，也未发现该基因多态性与CRC发病风险具有显著相关性。结论 VEGF+936C/T基因多态性与CRC发病风险不相关。为了更客观地评估二者的关联性，仍需扩大样本以进行进一步研究。 　　[关键词]结肠直肠癌；基因多态性；血管内皮生长因子；Meta分析 　　[中图分类号] R735.37 [文献标识码] A [文章编号] 1674-4721（2017）05（b）-0007-06 　　Correlation between vascular endothelial growth factor +936C/T polymorphism and colorectal cancer risk：a Meta analysis 　　ZHOU Chun-hua1 YUAN Song-quan2 LI Mei-zhen3 　　1.Department of Pulmonary/Gastrointestinal Diseases，Hunan Cancer Hospital （the Affiliated Cancer Hospital of Xiangya School of Medicine，Central South University） in Hunan Province，Changsha 410013，China；2.Zhuzhou Foreign Language School in Hunan Province，Zhuzhou 412000，China；3.Research Institute of Drug Metabolism and Pharmacokinetics，School of Pharmaceutical Sciences，Central South University in Hunan Province，Changsha 410000，China 　　[Abstract]Objective To investigate the association between the vascular endothelial growth factor （VEGF） gene +936C/T polymorphisms and colorectal cancer （CRC） risk.Methods Relevant published case-control studies were searched in PubMed，Embase and Medline databases，and all documents were updated to October 2016.A comprehensive meta-analysis was then performed with Review Manager 4.2 and Stata 11.0 software in this work.Results Finally 10 studies including 2860 cases and 3080 controls were brought into our meta-analysis.The association between VEGF+936C/T polymorphisms and CRC risk were calculated with OR