吡格列酮抑制胶原诱导性关节炎大鼠炎症性骨吸收作用的研究-内科学专业论文.docxVIP

吡格列 吡格列酮抑制胶原诱导性关节炎大鼠炎症性骨吸收作用的研究 广州医 广州医科大学硕士学位论文 PAGE PAGE 13 PAGE PAGE 10 性骨吸收。 2、吡格列酮可通过下调 CIA 大鼠关节软骨中的 RANKL 及血清中的 TNFα，通 过上调关节软骨、滑膜及血清中 OPG 的蛋白表达，起到一定的抑制 CIA 大鼠的 炎症性骨吸收的作用。吡格列酮抑制 CIA 大鼠的炎症性骨吸收的作用具有随剂 量增大而增强的趋势。 【关键词】吡格列酮；CIA 大鼠；炎症性骨吸收 The inhibitory effect of pioglitazone on inflammatory bone resorption in collagen-induced arthritis rats Major: Internal medicine Graduate student: Zongshun Huang Postgraduate tutor: Professor Yi Tao Abstract 【Backgroud and Obiectives】 Rheumatoid arthritis (RA) is systemic autoimmune disease characterized by chronic inflammation and synovium hyperplasia of peripheral joints, and finally leads to destruction of cartilage and subchondral bone. The destruction of cartilage and subchondral bone is irreversible and do great suffer to RA patients. Therefore, it is very important to prevent destruction of cartilage and subchondral bone when treating RA. Collagen induced arthritis (CIA) is one of the most common experimental modal of RA in domestic and overseas. They share many features in physiopathology, including high level of inflammatory factor like tumor necrosis factor α (TNF α) and interleukin-1(IL-1), inflammatory cells invasion, synovium hyperplasia and destruction of cartilage and subchondral bone. OPG/RANKL/RANK is an important system in the differentiation of osteoclast (OC), which is found recently. Receptor activator for nuclear factor-κB ligand (RANKL) is also called the differentiation factor of osteoclast. Its receptor is receptor activator for nuclear factor-κB(RANK), which is located on the surface of cell membrane of osteoclast precursor. Osteoprotegerin (OPG) is the decoy receptor of RANKL. It can compete with RANKL for RANK binding. The binding of RANKL expressed by activated T cell to RANK can promote the differentiation and mature of osteoclast precursor, and finally results in bone destruction or resorption. Therefore, RANKL can promote the destruction or resorption of cartilage and bone, while OPG can block