痹痛贴透皮贴剂的药学研究-药剂学专业论文.docxVIP

成都中医药大学硕士学位论文 成都中医药大学硕士学位论文 Abstract Objective: The preparation and evaluation of the transdermal patch of Bitong patch，a skeleton-controlled TDDS was developed.It is a basis for the development of the transdermal patch of Bitong through studying on its extraction process, molding process, the quality of preparation standards. Methods: The extraction technology research : ①To optimize the conditions of extraction technology of the volatile oil in the transdermal patch of Bitong by steam distillation．The L9(34) orthogonal design experiments were carried out，in which three influence factors，soaking time，amount of water and extraction time were selected， and the rate of volatile oil extracted were regarded as the evaluating indices.②L9 (34)table of orthogonal test was used to optimize the extraction process with alcohol concentration, alcohol quantity, extraction time and extraction number as the investigate factors，the content of osthole，dried cream yield as the indexes，to analyze the data of the technological condition of ethanol refluxing of dregs after Mentioning volatile oil and Radix Angelicae Pubescentis, Myrrh, Olibanum and other drugs in Prescription by Comprehensive Evaluation of Multiple marks.③Purified study on obtained decoction of the extraction of volatile oil. To optimize the conditions of Purification process of the obtained decoction of the extraction of volatile oil by Ethanol precipitation. The L9(34) orthogonal design experiments were carried out，in which three influence factors，the mass concentration of the initial liquid, the ethanol concentration of liquid and Alcohol precipitation time were selected, and the content of Ferulic acid，dried cream yield were regarded as the evaluating indices. The molding technology research: L9(34)table of orthogonal test was used to optimize the Preparation process with Eudragit RL 100，the amount of dibutyl sebacate，the amount of lanolin and the amount of Succinic acid as the examine factors，the appearance，i